Zn(OAc)2•2H2O-Catalyzed Betti Base Synthesis under Solvent-free Conditions

: Zn(OAc)2•2H2O-catalyzed one-pot multicomponent reaction of Betti bases using β-napthol, aldehydes, and amines, under neat conditions in moderate to excellent yields (68-96%) is reported. This synthetic protocol offers several advantages, such as operational simplicity, shorter reaction period, high yields, and easy work-up procedures.

Synthesis of new chiral N-alkyl Betti-base ligands via one-pot three component strategy

Background: Betti base derivatives were employed as chiral ligands or as chiral auxiliaries in asymmetric transformations. In particular, N-alkyl Betti base derivatives are gaining importance as excellent ligands in asymmetric reactions. However there is no appropriate method exists for regioselective N-alkylation of Betti base. Therefore there is an urgent need to develop a new protocol for the regioselective N-alkylation of chiral Betti-base. Methods: An efficient method has been developed for one-pot synthesis of chiral N-alkyl Betti-base ligands from (S)-(+)-Betti base, arylglyoxals and cyclic 1,3-C,N-binucleophiles under catalyst free conditions. Results: The chiral N-alkyl Betti-base ligands were obtained in good yields with excellent enantioselectivities. This method is a rapid, clean and does not require catalyst and chromatographic purification. Conclusion: We have developed an efficient one-pot three component strategy for the synthesis of new chiral N-alkyl Betti-base ligands from (S)-(+)-Betti base, arylglyoxals and cyclic 1,3-C,N-binucleophiles in the absence of catalyst.

Betti Base Derived P-Stereogenic Phosphine-Diamidophosphite Ligands with a Single Atom Spacer and their Application in Asymmetric Catalysis

A set of hybrid P-stereogenic phosphine-diamidophosphite ligands based on the Betti base backbone has been synthesized. The ligands possess five chiral centers including the P-chirality in both the phosphorus atoms....

Correction: Recent advances in the synthesis and synthetic applications of Betti base (aminoalkylnaphthol) and bis-Betti base derivatives

Correction for ‘Recent advances in the synthesis and synthetic applications of Betti base (aminoalkylnaphthol) and bis-Betti base derivatives’ by Olyaei et al., RSC Adv., 2019, 9, 18467–18497.

Recent advances in the synthesis and synthetic applications of Betti base (aminoalkylnaphthol) and bis-Betti base derivatives

The multicomponent reaction between 2-naphthol, arylaldehydes and ammonia yields aminobenzylnaphthols in a process known as the Betti reaction, which was first uncovered at the beginning of the 20th century.

Phosgene invites selective switch-on fluorescence at ppm concentrations in a Betti base by hindering 2-way PET

Phosgene ignites a decisive and immediate fluorescence response in a simple Betti base.