Copper-catalyzed enantioselective Mukaiyama aldol reaction of silyl enol ethers with isatins
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A highly enantioselective Mukaiyama aldol reaction of silyl enol ethers with isatins was developed. A series of chiral 3-substituted 3-hydroxy-2-oxindoles could be obtained exclusively with high yields (up to 95%) and excellent enantioselectivities (up to 99%). In particular, water was essential to improve the diastereoselectivity.
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1993 ◽
Vol 115
(15)
◽
pp. 7039-7040
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