Discovery of (aza)indole derivatives as novel respiratory syncytial virus fusion inhibitors

Indole Derivatives ◽

New Class ◽

Fusion Inhibitors ◽

Virus Fusion ◽

A new class of (aza)indole derivatives have been identified as potent RSV fusion inhibitors.

Faculty Opinions recommendation of Molecular mechanism of respiratory syncytial virus fusion inhibitors.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725996447.793512311 ◽

2015 ◽

Author(s):

Xiayang Qiu ◽

Ye Che

Keyword(s):

Molecular Mechanism ◽

Fusion Inhibitors ◽

Virus Fusion ◽

CHAPTER 2. Respiratory Syncytial Virus Fusion Inhibitors

Drug Discovery - Successful Strategies for the Discovery of Antiviral Drugs ◽

10.1039/9781849737814-00029 ◽

2013 ◽

pp. 29-62 ◽

Cited By ~ 2

Author(s):

David Sperandio ◽

Richard Mackman

Keyword(s):

Fusion Inhibitors ◽

Virus Fusion ◽

1,2,3,9b-Tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 2: Identification of BTA9881 as a preclinical candidate

10.1016/j.bmcl.2014.11.024 ◽

2015 ◽

Vol 25 (4) ◽

pp. 976-981 ◽

Cited By ~ 7

Author(s):

Silas Bond ◽

Alistair G. Draffan ◽

Jennifer E. Fenner ◽

John Lambert ◽

Chin Yu Lim ◽

...

Keyword(s):

New Class ◽

Fusion Inhibitors ◽

Discovery of Piperazinylquinoline Derivatives as Novel Respiratory Syncytial Virus Fusion Inhibitors

ACS Medicinal Chemistry Letters ◽

10.1021/acsmedchemlett.5b00234 ◽

2016 ◽

Vol 7 (6) ◽

pp. 558-562 ◽

Cited By ~ 18

Author(s):

Xiufang Zheng ◽

Lisha Wang ◽

Baoxia Wang ◽

Kun Miao ◽

Kunlun Xiang ◽

...

Keyword(s):

Fusion Inhibitors ◽

Virus Fusion ◽

The discovery of 1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 1

10.1016/j.bmcl.2014.11.018 ◽

2015 ◽

Vol 25 (4) ◽

pp. 969-975 ◽

Cited By ~ 9

Author(s):

Silas Bond ◽

Alistair G. Draffan ◽

Jennifer E. Fenner ◽

John Lambert ◽

Chin Yu Lim ◽

...

Keyword(s):

New Class ◽

Fusion Inhibitors ◽

Respiratory syncytial virus fusion inhibitors. Part 3: Water-soluble benzimidazol-2-one derivatives with antiviral activity in vivo

10.1016/j.bmcl.2005.11.109 ◽

2006 ◽

Vol 16 (5) ◽

pp. 1115-1122 ◽

Cited By ~ 27

Author(s):

Kuo-Long Yu ◽

Xiangdong Alan Wang ◽

Rita L. Civiello ◽

Ashok K. Trehan ◽

Bradley C. Pearce ◽

...

Keyword(s):

Antiviral Activity ◽

Water Soluble ◽

Fusion Inhibitors ◽

Virus Fusion ◽

Corrigendum to “Respiratory syncytial virus fusion inhibitors. Part 4: Optimization for oral bioavailability” [Bioorg. Med. Chem. Lett. 17 (2007) 895–901]

10.1016/j.bmcl.2007.03.020 ◽

2007 ◽

Vol 17 (8) ◽

pp. 2385

Author(s):

Kuo-Long Yu ◽

Ny Sin ◽

Rita L. Civiello ◽

X. Alan Wang ◽

Keith D. Combrink ◽

...

Keyword(s):

Oral Bioavailability ◽

Fusion Inhibitors ◽

Virus Fusion ◽

Respiratory syncytial virus fusion inhibitors. Part 7: Structure–activity relationships associated with a series of isatin oximes that demonstrate antiviral activity in vivo

10.1016/j.bmcl.2009.06.030 ◽

2009 ◽

Vol 19 (16) ◽

pp. 4857-4862 ◽

Cited By ~ 22

Author(s):

Ny Sin ◽

Brian L. Venables ◽

Keith D. Combrink ◽

H. Belgin Gulgeze ◽

Kuo-Long Yu ◽

...

Keyword(s):

Antiviral Activity ◽

Structure Activity Relationships ◽

Fusion Inhibitors ◽

Structure Activity ◽

Virus Fusion ◽

Discovery of Benzoazepinequinoline (BAQ) Derivatives as Novel, Potent, Orally Bioavailable Respiratory Syncytial Virus Fusion Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.8b01394 ◽

2018 ◽

Vol 61 (22) ◽

pp. 10228-10241 ◽

Cited By ~ 3

Author(s):

Xiufang Zheng ◽

Chungen Liang ◽

Lisha Wang ◽

Baoxia Wang ◽

Yongfu Liu ◽

...

Keyword(s):

Fusion Inhibitors ◽

Virus Fusion ◽

Orally Bioavailable ◽

Molecular mechanism of respiratory syncytial virus fusion inhibitors

Nature Chemical Biology ◽

10.1038/nchembio.1982 ◽

2015 ◽

Vol 12 (2) ◽

pp. 87-93 ◽

Cited By ~ 73

Author(s):

Michael B Battles ◽

Johannes P Langedijk ◽

Polina Furmanova-Hollenstein ◽

Supranee Chaiwatpongsakorn ◽

Heather M Costello ◽

...

Keyword(s):

Molecular Mechanism ◽

Fusion Inhibitors ◽

Virus Fusion ◽