C–C and C–X coupling reactions of unactivated alkyl electrophiles using copper catalysis

2020 ◽  
Vol 49 (22) ◽  
pp. 8036-8064 ◽  
Author(s):  
Li-Jie Cheng ◽  
Neal P. Mankad
Keyword(s):  
Cross Coupling ◽  
Copper Catalysts ◽  
Copper Catalysis ◽  
Coupling Reactions ◽  
Cross Coupling Reactions ◽  
Alkyl Electrophiles

Copper catalysts enable cross-coupling reactions of unactivated alkyl electrophiles to generate C–C and C–X bonds.

Striving to exploit alkyl electrophiles: challenge and choice in transition metal-catalyzed cross-coupling reactions of sulfones

2018 ◽  
Vol 5 (17) ◽  
pp. 2615-2617 ◽  
Author(s):  
Mengli Liu ◽  
Yannan Zheng ◽  
Guanyinsheng Qiu ◽  
Jie Wu
Keyword(s):  
Transition Metal ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Radical Process ◽  
Cross Coupling Reactions ◽  
Alkyl Electrophiles ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

Transition metal-catalyzed cross-coupling reactions of alkyl sulfones as crystalline and readily available alkyl electrophiles via a radical process are highlighted.

scholarly journals Modification of Azobenzenes by Cross-Coupling Reactions

Synthesis ◽  
2021 ◽  
Author(s):  
Anne Staubitz ◽  
Melanie Walther ◽  
Waldemar Kipke ◽  
Sven Schultzke ◽  
Souvik Ghosh
Keyword(s):  
Late Stage ◽  
Palladium Catalysis ◽  
Cross Coupling ◽  
Molecular Switches ◽  
Copper Catalysis ◽  
Coupling Reactions ◽  
Nickel Catalysis ◽  
Cross Coupling Reactions ◽  
Recent Developments

AbstractAzobenzenes are among the most extensively used molecular switches for many different applications. The need to tailor them to the required task often requires further functionalization. Cross-coupling reactions are ideally suited for late-stage modifications. This review provides an overview of recent developments in the modification of azobenzene and its derivatives by cross-coupling reactions.1 Introduction2 Azobenzenes as Formally Electrophilic Components2.1 Palladium Catalysis2.2 Nickel Catalysis2.3 Copper Catalysis2.4 Cobalt Catalysis3 Azobenzenes as Formally Nucleophilic Components3.1 Palladium Catalysis3.2 Copper Catalysis3.3 C–H Activation Reactions4 Azobenzenes as Ligands in Catalysts5 Diazocines5.1 Synthesis5.2 Cross-Coupling Reactions6 Conclusion

scholarly journals Ni(I)-Alkyl Complexes Bearing Phenanthroline Ligands: Experimental Evidence for CO2 Insertion at Ni(I) Centers

2020 ◽  
Author(s):  
Rosie Somerville ◽  
Carlota Odena ◽  
Marc Obst ◽  
Nilay Hazari ◽  
Kathrin Hopmann ◽  
...  
Keyword(s):  
Experimental Evidence ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Alkyl Complexes ◽  
Cross Coupling Reactions ◽  
Species Complexes ◽  
Alkyl Electrophiles ◽  
Metal Catalyzed ◽  
Phenanthroline Ligands

ABSTRACT: Although the catalytic carboxylation of unactivated alkyl electrophiles has reached remarkable levels of sophistication, the intermediacy of (phenanthroline)Ni(I)-alkyl species – complexes proposed in numerous Ni-catalyzed reductive cross-coupling reactions – has been subject to speculation. Herein, we report the synthesis of such elusive (phenanthroline)Ni(I) species and their reactivity with CO2, allowing us to address a long-standing challenge related to metal-catalyzed carboxylation reactions. <div> </div>

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