Nickel-catalyzed formation of quaternary carbon centers using tertiary alkyl electrophiles

2021 ◽  
Vol 50 (6) ◽  
pp. 4162-4184 ◽  
Author(s):  
Weichao Xue ◽  
Xiao Jia ◽  
Xuan Wang ◽  
Xianghua Tao ◽  
Zhigang Yin ◽  
...  
Keyword(s):  
Quaternary Carbon ◽  
Carbon Centers ◽  
Recent Advances ◽  
Alkyl Electrophiles ◽  
Catalyzed Reactions ◽  
Tertiary Alkyl

This review provides a comprehensive summary of recent advances in nickel-catalyzed reactions employing tertiary alkyl electrophiles for the construction of quaternary carbon centers.

Nickel-catalyzed reductive benzylation of tertiary alkyl halides with benzyl chlorides and chloroformates

2021 ◽  
Author(s):  
Jiabao Wang ◽  
Yuxin Gong ◽  
Deli Sun ◽  
Hegui Gong
Keyword(s):  
Alkyl Halides ◽  
Quaternary Carbon ◽  
Carbon Centers ◽  
Benzyl Chlorides ◽  
Tertiary Alkyl

We report a Ni-catalyzed cross-electrophile coupling of benzyl chlorides and chloroformates with unactivated tertiary alkyl halides to forge the challenging benzylated all C(sp3)-quaternary carbon centers.

Formation of allylated quaternary carbon centers via C–O/C–O bond fragmentation of oxalates and allyl carbonates

2020 ◽  
Vol 56 (3) ◽  
pp. 454-457 ◽  
Author(s):  
Haifeng Chen ◽  
Yang Ye ◽  
Weiqi Tong ◽  
Jianhui Fang ◽  
Hegui Gong
Keyword(s):  
Fragmentation Process ◽  
Reductive Coupling ◽  
Quaternary Carbon ◽  
Carbon Centers ◽  
Tertiary Alkyl

Fe-Promoted reductive coupling of tertiary alkyl oxalates with allylic carbonates enables the formation of all C(sp3)–quaternary carbon centers via a double C–O bond fragmentation process.

Stereocontrolled Synthesis of Highly Functionalized Quaternary Carbon Centers: A Route to α-Substituted Serines

2009 ◽  
Vol 121 (23) ◽  
pp. 4266-4269 ◽  
Author(s):  
Xavier Ariza ◽  
Josep Cornellà ◽  
Mercè Font-Bardia ◽  
Jordi Garcia ◽  
Jordi Ortiz ◽  
...  
Keyword(s):  
Quaternary Carbon ◽  
Carbon Centers ◽  
Stereocontrolled Synthesis

Alkylation of (η6-arene) - Ru(II) complexes: Construction of benzylic quaternary carbon centers

1999 ◽  
Vol 40 (12) ◽  
pp. 2251-2254 ◽  
Author(s):  
F.Christopher Pigge ◽  
Shiyue Fang ◽  
Nigam P Rath
Keyword(s):  
Quaternary Carbon ◽  
Carbon Centers
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