tertiary alkyl
Recently Published Documents


TOTAL DOCUMENTS

461
(FIVE YEARS 42)

H-INDEX

41
(FIVE YEARS 4)

2022 ◽  
Author(s):  
Jose Aleman

Abstract Herein, we report, for the first time, a general, facile and environmentally friendly Minisci-type alkylation of N-heteroarenes under simple and straightforward electrochemical conditions using widely available alkyl halides as radical precursors. Primary, secondary and tertiary alkyl radicals have shown to be efficiently generated and coupled with a large variety of N-heteroarenes. The method presents a very high functional group tolerance, including various heterocyclic-based natural products, which highlights the robustness of the methodology. This applicability has been further proved in the synthesis of various interesting biologically valuable building blocks. In addition, we have proposed a mechanism based on different proofs and electrochemical evidences.


2021 ◽  
pp. 153604
Author(s):  
Bing Xu ◽  
Yang Ye ◽  
Ying Lin ◽  
Renren Bai ◽  
Xiang-Yang Ye ◽  
...  
Keyword(s):  

2021 ◽  
Author(s):  
Regina M. Oechsner ◽  
J. Philipp Wagner ◽  
Ivana Fleischer

We report a mild, fast and convenient catalytic system for the coupling of aryl chlorides with primary, secondary, as well as previously challenging tertiary alkyl thiols using an air-stable nickel(II) precatayst in combination with the low-cost base potassium acetate at room temperature. This new catalytic system tolerates a variety of functional groups and enables the generation of thioethers for a wide range of substrates, including pharmaceutical compounds in excellent yields. Chemoselec-tive functionalization of disubstituted substrates was demonstrated. Kinetic and NMR-studies, as well as DFT computations support a Ni(0)/Ni(II) catalytic cycle and identify the oxidative addition product as the resting state. Acetate coordination and subsequent acetate facilitated formation of a thiolate complex via internal deprotonation play a key role in the catalytic cycle.


ACS Catalysis ◽  
2021 ◽  
Vol 11 (18) ◽  
pp. 11526-11531
Author(s):  
Yusei Nakashima ◽  
Junki Matsumoto ◽  
Takashi Nishikata
Keyword(s):  

ACS Catalysis ◽  
2021 ◽  
pp. 7070-7079
Author(s):  
Fang-Fang Feng ◽  
Xuan-Yu Liu ◽  
Chi Wai Cheung ◽  
Jun-An Ma
Keyword(s):  

2021 ◽  
Author(s):  
Bayu Ardiansah ◽  
Hiroki Tanimoto ◽  
Takenori Tomohiro ◽  
Tsumoru Morimoto ◽  
Kiyomi Kakiuchi

Schmidt reaction by sulfonium ions is described. General primary, secondary, and tertiary alkyl azides were converted to the corresponding carbonyl or imine compounds without any trace of the activators. This bond scission reaction showcased ring-opening, -expansion, and one-pot further conversion of the substrates as well as the application with C-H azidation.


2021 ◽  
Author(s):  
Bayu Ardiansah ◽  
Hiroki Tanimoto ◽  
Takenori Tomohiro ◽  
Tsumoru Morimoto ◽  
Kiyomi Kakiuchi

Schmidt reaction by sulfonium ions is described. General primary, secondary, and tertiary alkyl azides were converted to the corresponding carbonyl or imine compounds without any trace of the activators. This bond scission reaction showcased ring-opening, -expansion, and one-pot further conversion of the substrates as well as the application with C-H azidation.


2021 ◽  
Author(s):  
Bayu Ardiansah ◽  
Hiroki Tanimoto ◽  
Takenori Tomohiro ◽  
Tsumoru Morimoto ◽  
Kiyomi Kakiuchi

Schmidt reaction by sulfonium ions is described. General primary, secondary, and tertiary alkyl azides were converted to the corresponding carbonyl or imine compounds without any trace of the activators. This bond scission reaction showcased ring-opening, -expansion, and one-pot further conversion of the substrates as well as the application with C-H azidation.


2021 ◽  
Vol 23 (3) ◽  
pp. 1005-1010
Author(s):  
Yuxin Gong ◽  
Zhaodong Zhu ◽  
Qun Qian ◽  
Weiqi Tong ◽  
Hegui Gong

Sign in / Sign up

Export Citation Format

Share Document