Determination of the correlation between the structure and dynamics of deflazacort by solid state NMR measurements

2020 ◽  
Vol 44 (42) ◽  
pp. 18419-18430 ◽  
Author(s):  
Krishna Kishor Dey ◽  
Manasi Ghosh
Keyword(s):  
Relaxation Time ◽  
Solid State ◽  
Solid State Nmr ◽  
Lattice Relaxation ◽  
Lattice Relaxation Time ◽  
Spin Lattice Relaxation ◽  
Spin Lattice Relaxation Time ◽  
Spin Lattice ◽  
Structure And Dynamics

The correlation between the structure and dynamics of glucocorticoid deflazacort is determined by a 2DPASS CP-MAS SSNMR experiment and 13C spin–lattice relaxation time by a Torchia CP experiment.

The Use of Solid State NMR to Evaluate EVA/Silica FILMs

2012 ◽  
Vol 18-19 ◽  
pp. 219-226 ◽  
Author(s):  
Adriano Alves Passos ◽  
Maria Inês Bruno Tavares ◽  
Roberto Cucinelli P. Neto ◽  
Antonio G. Ferreira
Keyword(s):  
Relaxation Time ◽  
Solid State ◽  
Solid State Nmr ◽  
Lattice Relaxation ◽  
Lattice Relaxation Time ◽  
Proton Spin ◽  
Spin Lattice Relaxation ◽  
Spin Lattice Relaxation Time ◽  
Spin Lattice ◽  
Silica Oxide

Nanocomposites based on ethylene-co-vinyl acetate (EVA) and silica oxide (SiO2), with nanometric size (40nm) were prepared by solution process, employing chloroform as solvent. The nanocomposites were mainly characterized by solid state nuclear magnetic resonance spectroscopy (NMR). From the methodology employed polymer matrix was evaluated by the determination of proton nuclear spin-lattice relaxation time (T1H) and spin-spin relaxation time (T2H) employing low field NMR spectrometer and also applying carbon-13 (13C) solid-state NMR techniques and proton spin-lattice relaxation time in the rotating frame (T1pH) by high field NMR. The nanoparticle, silica oxide, was analyzed by silicon-29 (29Si) NMR MAS spectrum. The evaluation of relaxation time showed an increase in the proton spin-lattice relaxation time, because of silicon nucleus interaction with polymer chains promoting an increase in the sample rigidity, which is a result of good silica oxide dispersion in the polymeric matrix. The nanomaterial with 5% of SiO2presented good dispersion of silica oxide in the polymeric matrix, because of the formation of strong intermolecular interaction.

scholarly journals Understanding the structure and dynamics of anti-inflammatory corticosteroid dexamethasone by solid state NMR spectroscopy

RSC Advances ◽  
2020 ◽  
Vol 10 (61) ◽  
pp. 37564-37575
Author(s):  
Krishna Kishor Dey ◽  
Manasi Ghosh
Keyword(s):  
Relaxation Time ◽  
Solid State ◽  
Nmr Spectroscopy ◽  
Solid State Nmr ◽  
Lattice Relaxation ◽  
Lattice Relaxation Time ◽  
Spin Lattice Relaxation ◽  
Site Specific ◽  
Spin Lattice ◽  
Structure And Dynamics

The structure and dynamics of dexamethasone is determined by measuring CSA tensor, site-specific spin–lattice relaxation time.

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