scholarly journals Rapid synthesis of internal peptidyl α-ketoamides by on resin oxidation for the construction of rhomboid protease inhibitors

RSC Advances ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 4196-4199
Author(s):  
Tim Van Kersavond ◽  
Raphael Konopatzki ◽  
Merel A. T. van der Plassche ◽  
Jian Yang ◽  
Steven H. L. Verhelst
Keyword(s):  
Protease Inhibitors ◽  
Serine Proteases ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Biological Processes ◽  
Protease Inhibition ◽  
Rapid Synthesis ◽  
Phase Synthesis ◽  
Rhomboid Protease

Rhomboid intramembrane serine proteases are involved in various biological processes. A solid phase synthesis of internal α-ketoamides reported here shows that primed site elements are crucial for rhomboid protease inhibition.

Solid-phase synthesis of potential aspartic acid protease inhibitors containing a hydroxyethylamine isostere

1999 ◽  
Vol 40 (14) ◽  
pp. 2729-2732 ◽  
Author(s):  
Jinglan Zhou ◽  
Andreas Termin ◽  
Melissa Wayland ◽  
Christine M. Tarby
Keyword(s):  
Protease Inhibitors ◽  
Aspartic Acid ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Acid Protease ◽  
Phase Synthesis

Solid-phase synthesis of benzisothiazolones as serine protease inhibitors

1999 ◽  
Vol 9 (5) ◽  
pp. 663-666 ◽  
Author(s):  
Kuo-Long Yu ◽  
Rita Civiello ◽  
Daniel G.M. Roberts ◽  
Steven M. Seiler ◽  
Nicholas A. Meanwell
Keyword(s):  
Serine Protease ◽  
Protease Inhibitors ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Serine Protease Inhibitors ◽  
Phase Synthesis

Expedited Solid-Phase Synthesis of Fluorescently Labeled and Biotinylated Aminoalkane Diphenyl Phosphonate Affinity Probes for Chymotrypsin- and Elastase-Like Serine Proteases

2009 ◽  
Vol 20 (11) ◽  
pp. 2098-2105 ◽  
Author(s):  
Brendan F. Gilmore ◽  
Derek J. Quinn ◽  
Thomas Duff ◽  
George R. Cathcart ◽  
Christopher J. Scott ◽  
...  
Keyword(s):  
Serine Proteases ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Affinity Probes

Solid-phase synthesis of a library based on biphenyl-containing trypsin-like serine protease inhibitors

2009 ◽  
Vol 19 (22) ◽  
pp. 6477-6480 ◽  
Author(s):  
Shuhao Shi ◽  
Shirong Zhu ◽  
Samuel W. Gerritz ◽  
Bogumila Rachwal ◽  
Zheming Ruan ◽  
...  
Keyword(s):  
Serine Protease ◽  
Protease Inhibitors ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Serine Protease Inhibitors ◽  
Phase Synthesis

scholarly journals Rapid synthesis of oligodeoxyribonucleotides IV. Improved solid phase synthesis of oligodeoxy-ribonucleotides through phosphotriester intermediates

1980 ◽  
Vol 8 (5) ◽  
pp. 1081-1096 ◽  
Author(s):  
M.J. Gait ◽  
M. Singh ◽  
R.C. Sheppard ◽  
M.D. Edge ◽  
A.R. Greene ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Rapid Synthesis ◽  
Phase Synthesis
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