Delivery of Cas13a/crRNA by self-degradable black phosphorus nanosheets to specifically inhibit Mcl-1 for breast cancer therapy

2020 ◽  
Vol 8 (48) ◽  
pp. 11096-11106
Author(s):  
Huahua Yue ◽  
Ru Huang ◽  
Yuanyue Shan ◽  
Da Xing
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Black Phosphorus ◽  
Endosomal Escape ◽  
Transcriptional Level ◽  
Breast Cancer Therapy

The constructed Cas13a/crRNA complex is delivered into cytoplasm by PBP via endocytosis, followed by endosomal escape based on biodegradation of the PBP, and efficiently knocked down Mcl-1 at transcriptional level for breast cancer therapy.

scholarly journals ICG-Loaded PEG-Modified Black Phosphorus Nanosheets for Fluorescence Imaging-Guided Breast Cancer Therapy

ACS Omega ◽  
2021 ◽  
Author(s):  
Wanwan Pan ◽  
Weijian Chen ◽  
Yuanzeng Min ◽  
Jing Wang ◽  
Zhenye Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Fluorescence Imaging ◽  
Black Phosphorus ◽  
Breast Cancer Therapy

(TA)MUC1 as a potential new target for breast cancer therapy

2020 ◽  
Author(s):  
AS Heimes ◽  
P Fries ◽  
N Stergiou ◽  
R Attariya ◽  
A Hasenburg ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Breast Cancer Therapy

Off-label drug use in breast cancer therapy

Oncoreview ◽  
2017 ◽  
Vol 7 (2) ◽  
pp. 83-87
Author(s):  
Tomasz Jankowski ◽  
Monika Urbaniak
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Drug Use ◽  
Breast Cancer Therapy ◽  
Off Label
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