Enantioselective formal [2+2+2] cycloaddition of 1,3,5-triazinanes to construct tetrahydropyrimidin-4-one derivatives
A chiral Lewis acid-catalyzed enantioselective formal [2+2+2] cycloaddition of 1,3,5-triazinanes with azlactones or β,γ-unsaturated pyrazole amides were developed to synthesize chiral tertiary/quaternary tetrahydropyrimidin-4-one derivatives with good yields and enantioselectivities. Two...
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