scholarly journals Ligand substituent effect on the cytotoxicity activity of two new copper(ii) complexes bearing 8-hydroxyquinoline derivatives: validated by MTT assay and apoptosis in MCF-7 cancer cell line (human breast cancer)

RSC Advances ◽  
2021 ◽  
Vol 11 (24) ◽  
pp. 14362-14373
Author(s):  
Arif Ali ◽  
Somesh Banerjee ◽  
Saima Kamaal ◽  
Mohammad Usman ◽  
Neeladrisingha Das ◽  
...  

The presence of –COOH functionality in a copper(ii) complex leads to higher cytotoxicity than that observed for a complex containing a –CN group.

2021 ◽  
Vol 66 (1) ◽  
pp. 65-71
Author(s):  
Hung Nguyen Phi ◽  
Toan Tran Quoc ◽  
Tuan Nguyen Anh ◽  
Vy Trinh Ngoc Thao ◽  
Yen Ngo Thi Ngoc ◽  
...  

Three alkaloids (named rutaecarpine (1), evodiamine (2), schinifoline (3) and one phenylpropanoid, integrifoliodiol (4)) have been isolated from the EtOAc extract of the fruits of Tetradium ruticarpum (A. Juss.) T. G. Hartley collected in Lang Son province. Their structures have been identified by using 1D and 2D NMR spectroscopies. All four compounds were tested for their cytotoxicity against the human breast cancer cell line (MCF-7) and tamoxifen-resistant breast cancer cell line (MCF\TAMR). The results showed that rutaecarpine (1) inhibited the growth of MCF7 and MCF\TAMR with its IC50 values of 41.2 and 64.6 µM, respectively. In addition, compounds 1, 2, and 4 showed moderate activity toward MCF-7 cell line.


2003 ◽  
Vol 32 (8) ◽  
pp. 1595-1603 ◽  
Author(s):  
J. Vassy ◽  
S. Portet ◽  
M. Beil ◽  
G. Millot ◽  
F. Fauvel-Lafève ◽  
...  

2003 ◽  
Vol 144 ◽  
pp. s180
Author(s):  
E. Chiesara ◽  
R. Fumagalli ◽  
M. Ferraris ◽  
S. Frigerio ◽  
L. Marabini ◽  
...  

2010 ◽  
Vol 48 (3) ◽  
pp. 269-274 ◽  
Author(s):  
Wahid Chaouki ◽  
David Y. Leger ◽  
Jamila Eljastimi ◽  
Jean-Louis Beneytout ◽  
Mohamed Hmamouchi

2021 ◽  
Vol 17 ◽  
pp. 12-12
Author(s):  
Dominika Komorowska ◽  
Agnieszka Gajewska ◽  
Aleksandra Rodacka

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