scholarly journals A Dynamic Picture of the Halolactonization Reaction through a Combination of ab-initio Metadynamics and Experimental Investigations .

2021 ◽  
Author(s):  
Ruben Van Lommel ◽  
Jonathan Bock ◽  
Constantin Daniliuc ◽  
Ulrich Hennecke ◽  
Frank De Proft
Keyword(s):  
Ab Initio ◽  
Electrophilic Addition ◽  
Experimental Investigations ◽  
Addition Reactions

The halolactonization reaction is one of the most common electrophilic addition reactions to alkenes. The mechanism is generally viewed as a two-step pathway, which involves the formation of an ionic...

ELECTROPHILIC ADDITION REACTIONS OF FLUORO-OLEFINS

1966 ◽  
Vol 35 (6) ◽  
pp. 417-427 ◽  
Author(s):  
B L Dyatkin ◽  
E P Mochalina ◽  
Ivan L Knunyants
Keyword(s):  
Electrophilic Addition ◽  
Addition Reactions

Lithiated oxazolinyloxiranes and oxazolinylaziridines: key players in organic synthesis

2014 ◽  
Vol 86 (6) ◽  
pp. 913-924 ◽  
Author(s):  
Saverio Florio ◽  
Leonardo Degennaro ◽  
Rosmara Mansueto ◽  
Biagia Musio ◽  
Filippo M. Perna ◽  
...  
Keyword(s):  
Ab Initio Calculations ◽  
Ab Initio ◽  
Organic Synthesis ◽  
Spectroscopic Data ◽  
Chemical Properties ◽  
Structural Features ◽  
Addition Reactions ◽  
Electronic Effects ◽  
Key Players ◽  
Ir Spectroscopic

AbstractThis paper focuses on α-lithiated oxazolinyloxiranes and oxazolinylaziridines, their generation, reactions, and synthetic applications. The ability of the oxazoline ring in providing stabilization to such α-heterosubstituted carbanions either through electronic effects and coordinative action has been stressed as well as the contribution to the configurational stability or instability of such species. IR spectroscopic data, multinuclear NMR investigations, and ab initio calculations planned to get insights on chemical properties and structural features have been carried out. A number of new reactions including alkylations, addition reactions, hydroxyalkylations, cyclopropanations, lactonizations, and rearrangements have been discovered, giving access to a variety of substances including: aziridinolactones, epoxylactones, aryl alkanones, polysubstituted cyclopropanes, cyclopropanefused lactones, dihydro-oxazoloisoquinolines, diversely functionalized oxazolines, and products that can be derived from them by synthetic elaboration.

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