scholarly journals Catalytic Enantioselective Synthesis of Benzocyclobutenols and Cyclobutanols via A Sequential Reduction/C-H Functionalization

2021 ◽  
Author(s):  
Jun Chen ◽  
Zhan Shi ◽  
Chunyu Li ◽  
Ping Lu
Keyword(s):  
Enantioselective Synthesis ◽  
Enantioselective Reduction ◽  
Carbon Centers ◽  
Sequential Reduction

We report here a sequential enantioselective reduction/C-H functionalization to install contiguous stereogenic carbon centers of benzocyclobutenols and cyclobutanols. This strategy features a practical enantioselective reduction of ketone and a diastereospecific...

Modular, Stereocontrolled Cβ–H/Cα–C Activation of Alkyl Carboxylic Acids

2019 ◽  
Author(s):  
Ming Shang ◽  
Karla S. Feu ◽  
Julien C. Vantourout ◽  
Lisa M. Barton ◽  
Heather L. Osswald ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Heterocyclic Compounds ◽  
Cross Coupling ◽  
Building Blocks ◽  
Enantioselective Synthesis ◽  
Carbon Centers ◽  
Drug Candidates ◽  
Rapid Diversification ◽  
Directing Group ◽  
Compound Series

<div> <div> <div> <p>The union of two powerful transformations, directed C–H activation and decarboxylative cross-coupling, for the enantioselective synthesis of vicinally functionalized alkyl, carbocyclic, and heterocyclic compounds is described. Starting from simple carboxylic acid building blocks, this modular sequence exploits the residual directing group to access more than 50 scaffolds that would be otherwise extremely difficult to prepare. The tactical use of these two transformations accomplishes a formal vicinal difunctionalization of carbon centers in a way that is modular and thus amenable to rapid diversity incorporation. A simplification of routes to known preclinical drug candidates is presented along with the rapid diversification of an antimalarial compound series. </p> </div> </div> </div>

Enantioselective Synthesis of Polycyclic γ-Lactams with Multiple Chiral Carbon Centers via Ni(0)-Catalyzed Asymmetric Carbonylative Cycloadditions without Stirring

2019 ◽  
Vol 142 (3) ◽  
pp. 1594-1602 ◽  
Author(s):  
Keita Ashida ◽  
Yoichi Hoshimoto ◽  
Norimitsu Tohnai ◽  
David E. Scott ◽  
Masato Ohashi ◽  
...  
Keyword(s):  
Enantioselective Synthesis ◽  
Carbon Centers ◽  
Chiral Carbon

ChemInform Abstract: Enantioselective Synthesis of Cyclopropanes that Contain Fluorinated Tertiary Stereogenic Carbon Centers: A Chiral α-Fluoro Carbanion Strategy.

ChemInform ◽  
2012 ◽  
Vol 43 (49) ◽  
pp. no-no
Author(s):  
Xiao Shen ◽  
Wei Zhang ◽  
Lei Zhang ◽  
Tao Luo ◽  
Xiaolong Wan ◽  
...  
Keyword(s):  
Enantioselective Synthesis ◽  
Carbon Centers

Enantioselective Synthesis of Cyclopropanes That Contain Fluorinated Tertiary Stereogenic Carbon Centers: A Chiral α-Fluoro Carbanion Strategy

2012 ◽  
Vol 124 (28) ◽  
pp. 7072-7076 ◽  
Author(s):  
Xiao Shen ◽  
Wei Zhang ◽  
Lei Zhang ◽  
Tao Luo ◽  
Xiaolong Wan ◽  
...  
Keyword(s):  
Enantioselective Synthesis ◽  
Carbon Centers
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