Resveratrol promotes degradation of the human bile acid transporter ASBT (SLC10A2)

2014 ◽  
Vol 459 (2) ◽  
pp. 301-312 ◽  
Author(s):  
Paresh P. Chothe ◽  
Peter W. Swaan
Keyword(s):  
Bile Acid ◽  
Human Bile ◽  
Ubiquitin Proteasome ◽  
Bile Acid Transporter ◽  
Acid Transporter

hASBT is negatively regulated by resveratrol, which acts by promoting ubiquitin–proteasome-mediated degradation of hASBT. The effect was specific, SIRT1-independent and does not require phosphorylation.

scholarly journals Human bile acid transporter ASBT (SLC10A2) forms functional non-covalent homodimers and higher order oligomers

2018 ◽  
Vol 1860 (3) ◽  
pp. 645-653 ◽  
Author(s):  
Paresh P. Chothe ◽  
Lindsay C. Czuba ◽  
Robyn H. Moore ◽  
Peter W. Swaan
Keyword(s):  
Bile Acid ◽  
Higher Order ◽  
Human Bile ◽  
Bile Acid Transporter ◽  
Acid Transporter

scholarly journals Degradation of the Apical Sodium-dependent Bile Acid Transporter by the Ubiquitin-Proteasome Pathway in Cholangiocytes

2004 ◽  
Vol 279 (43) ◽  
pp. 44931-44937 ◽  
Author(s):  
Xuefeng Xia ◽  
Marlon Roundtree ◽  
Afkhamossadat Merikhi ◽  
Xiaohui Lu ◽  
Shujun Shentu ◽  
...  
Keyword(s):  
Bile Acid ◽  
Ubiquitin Proteasome Pathway ◽  
Sodium Dependent ◽  
Ubiquitin Proteasome ◽  
Bile Acid Transporter ◽  
Proteasome Pathway ◽  
Acid Transporter

scholarly journals Transmembrane Domain V Plays a Stabilizing Role in the Function of Human Bile Acid Transporter SLC10A2

Biochemistry ◽  
2013 ◽  
Vol 52 (30) ◽  
pp. 5117-5124 ◽  
Author(s):  
Robyn H. Moore ◽  
Paresh Chothe ◽  
Peter W. Swaan
Keyword(s):  
Bile Acid ◽  
Transmembrane Domain ◽  
Human Bile ◽  
Bile Acid Transporter ◽  
Acid Transporter ◽  
Domain V

scholarly journals Transmembrane Domain II of the Human Bile Acid Transporter SLC10A2 Coordinates Sodium Translocation

2013 ◽  
Vol 288 (45) ◽  
pp. 32394-32404 ◽  
Author(s):  
Hairat Sabit ◽  
Sairam S. Mallajosyula ◽  
Alexander D. MacKerell ◽  
Peter W. Swaan
Keyword(s):  
Bile Acid ◽  
Transmembrane Domain ◽  
Human Bile ◽  
Bile Acid Transporter ◽  
Acid Transporter
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