scholarly journals A natural recessive resistance gene against potato virus Y in pepper corresponds to the eukaryotic initiation factor 4E (eIF4E)

2002 ◽  
Vol 32 (6) ◽  
pp. 1067-1075 ◽  
Author(s):  
Sandrine Ruffel ◽  
Marie-Hélène Dussault ◽  
Alain Palloix ◽  
Benoît Moury ◽  
Abdelhafid Bendahmane ◽  
...  
Keyword(s):  
Resistance Gene ◽  
Potato Virus ◽  
Potato Virus Y ◽  
Initiation Factor ◽  
Eukaryotic Initiation Factor ◽  
Recessive Resistance ◽  
Recessive Resistance Gene ◽  
Eukaryotic Initiation Factor 4E

Impact of tobacco recessive resistance gene va on biological properties of Brazilian Potato virus Y (PVY) isolates

2011 ◽  
Vol 60 (6) ◽  
pp. 1048-1054 ◽  
Author(s):  
C. Lacroix ◽  
L. Glais ◽  
J.-L. Verrier ◽  
C. Charlier ◽  
C. Lorencetti ◽  
...  
Keyword(s):  
Resistance Gene ◽  
Potato Virus ◽  
Potato Virus Y ◽  
Biological Properties ◽  
Recessive Resistance ◽  
Recessive Resistance Gene

scholarly journals Evolutionary Pathways to Break Down the Resistance of Allelic Versions of the PVY Resistance Gene va

Plant Disease ◽  
2014 ◽  
Vol 98 (11) ◽  
pp. 1521-1529 ◽  
Author(s):  
B. Janzac ◽  
M. Tribodet ◽  
C. Lacroix ◽  
B. Moury ◽  
J. L. Verrier ◽  
...  
Keyword(s):  
Resistance Gene ◽  
Potato Virus Y ◽  
Control Strategies ◽  
Wild Type ◽  
Recessive Resistance ◽  
Evolutionary Pathway ◽  
Recessive Resistance Gene ◽  
Pvy Resistance ◽  
Infectious Clones ◽  
Host Genetic

Emergence of viral genotypes can make control strategies based on resistance genes ineffective. A few years after the deployment of tobacco genotypes carrying alleles of the Potato virus Y (PVY) recessive resistance gene va, virulent PVY isolates have been reported, suggesting the low durability of va. To have a broader view of the evolutionary processes involved in PVY adaptation to va, we studied mutational pathways leading to the emergence of PVY resistance-breaking populations. The viral genome-linked protein (VPg) has been described to be potentially involved in va adaptation. Analyses of the VPg sequence of PVY isolates sampled from susceptible and resistant tobacco allowed us to identify mutations in the central part of the VPg. Analysis of the virulence of wild-type isolates with known VPg sequences and of mutated versions of PVY infectious clones allowed us to (i) validate VPg as the PVY virulence factor corresponding to va, (ii) highlight the fact that virulence gain in PVY occurs rapidly and preferentially by substitution at position AA105 in the VPg, and (iii) show that the 101G substitution in the VPg of a PVYC isolate is responsible for cross-virulence toward two resistance sources. Moreover, it appears that the evolutionary pathway of PVY adaptation to va depends on both virus and host genetic backgrounds.

scholarly journals Phosphorylation of eukaryotic initiation factor 4E (eIF4E) at Ser209 is not required for protein synthesis in vitro and in vivo

2001 ◽  
Vol 268 (20) ◽  
pp. 5375-5385 ◽  
Author(s):  
Linda McKendrick ◽  
Simon J. Morley ◽  
Virginia M. Pain ◽  
Rosemary Jagus ◽  
Bhavesh Joshi
Keyword(s):  
Protein Synthesis ◽  
Initiation Factor ◽  
Eukaryotic Initiation Factor ◽  
Eukaryotic Initiation Factor 4E

Thermodynamics of Molecular Recognition of mRNA 5′ Cap by Yeast Eukaryotic Initiation Factor 4E

2011 ◽  
Vol 115 (27) ◽  
pp. 8746-8754 ◽  
Author(s):  
Katarzyna Kiraga-Motoszko ◽  
Anna Niedzwiecka ◽  
Anna Modrak-Wojcik ◽  
Janusz Stepinski ◽  
Edward Darzynkiewicz ◽  
...  
Keyword(s):  
Molecular Recognition ◽  
Initiation Factor ◽  
Eukaryotic Initiation Factor ◽  
Eukaryotic Initiation Factor 4E
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