scholarly journals Salvage endoscopic resection in patients with esophageal adenocarcinoma after chemoradiotherapy

2018 ◽  
Vol 06 (09) ◽  
pp. E1126-E1129 ◽  
Author(s):  
Irma C. Noordzij ◽  
Wouter L. Curvers ◽  
Clément J. Huysentruyt ◽  
Grard A.P. Nieuwenhuijzen ◽  
Geert-Jan Creemers ◽  
...  
Keyword(s):  
Esophageal Adenocarcinoma ◽  
Endoscopic Resection ◽  
Argon Plasma Coagulation ◽  
Case Series ◽  
Argon Plasma ◽  
Residual Tumor ◽  
Esophageal Resection ◽  
Sustained Remission ◽  
Long Term Prognosis

Abstract Background and study aims For early esophageal adenocarcinoma, endoscopic resection is an accepted curative treatment with an excellent long-term prognosis. Case series from Japan have reported endoscopic resection of residual esophageal squamous cell carcinoma after chemoradiotherapy. This is the first report describing endoscopic resection of residual esophageal adenocarcinoma after chemoradiotherapy. Two patients with advanced esophageal adenocarcinoma had been treated with chemoradiotherapy because comorbidity precluded esophageal resection. When residual tumor was observed endoscopically, complete remission was achieved by salvage endoscopic therapy alone or in combination with argon plasma coagulation (APC). Both patients achieved long-term sustained remission and died of non-tumor-related causes.

Sa1645 Argon Plasma Coagulation for the Treatment of Superficial Gastric Neoplasm With Lateral Margin Positivity After Endoscopic Resection

2014 ◽  
Vol 79 (5) ◽  
pp. AB287
Author(s):  
Joo Young Cho ◽  
Weon-Jin Ko ◽  
MI-Young Kim ◽  
Jun-Hyung Cho ◽  
Seong Ran Jeon ◽  
...  
Keyword(s):  
Endoscopic Resection ◽  
Argon Plasma Coagulation ◽  
Argon Plasma ◽  
Gastric Neoplasm ◽  
Lateral Margin ◽  
Plasma Coagulation

scholarly journals Successful treatment of refractory Barrett’s neoplasia with hybrid argon plasma coagulation: a case series

Endoscopy ◽  
2020 ◽  
Vol 52 (09) ◽  
pp. 812-813 ◽  
Author(s):  
Arvind J. Trindade ◽  
Diana Wee ◽  
Praneet Wander ◽  
Molly Stewart ◽  
Calvin Lee ◽  
...  
Keyword(s):  
Successful Treatment ◽  
Argon Plasma Coagulation ◽  
Case Series ◽  
Argon Plasma ◽  
Plasma Coagulation

scholarly journals A Case Series of Patients with Isolated IgG4-related Hypophysitis Treated with Rituximab

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Hessa Boharoon ◽  
James Tomlinson ◽  
Clara Limback-Stanic ◽  
Anastasia Gontsorova ◽  
Niamh Martin ◽  
...  
Keyword(s):  
Case Series ◽  
Disease Process ◽  
High Recurrence Rate ◽  
Sustained Remission ◽  
Mri Findings ◽  
Immunoglobulin G4 ◽  
Igg4 Related Disease ◽  
Anterior Pituitary Function ◽  
Pituitary Enlargement

Abstract Context The acute presentation of immunoglobulin G4 (IgG4)-related hypophysitis can be indistinguishable from other forms of acute hypophysitis, and histology remains the diagnostic gold standard. The high recurrence rate necessitates long-term immunosuppressive therapy. Rituximab (RTX) has been shown to be effective in systemic IgG4-related disease (IgG4-RD), but experience with isolated pituitary involvement remains limited. Case Description We report 3 female patients with MRI findings suggestive of hypophysitis. All patients underwent transsphenoidal biopsy and fulfilled diagnostic criteria for IgG4-related hypophysitis. Treatment with glucocorticoids (GCs) resulted in good therapeutic response in Patients 1 and 2, but the disease recurred on tapering doses of GCs. GC treatment led to emotional lability in Patient 3, necessitating a dose reduction. All 3 patients received RTX and Patients 2 and 3 received further courses of treatment when symptoms returned and B-cells repopulated. Patient 3 did not receive RTX until 12 months from the onset of symptoms. Patient 1 was not able to have further RTX treatments due to an allergic reaction when receiving the second dose. Rituximab treatment resulted in sustained remission and full recovery of anterior pituitary function in Patients 1 and 2, with complete resolution of pituitary enlargement. By contrast, Patient 3 only showed a symptomatic response following RTX treatment, but pituitary enlargement and hypofunction persisted. Conclusion Rituximab treatment for IgG4-related hypophysitis resulted in sustained remission in 2 patients treated early in the disease process but only achieved partial response in a patient with chronic disease, suggesting that early therapeutic intervention may be crucial in order to avoid irreversible changes.

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