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2022 ◽  
Vol 78 ◽  
pp. 110650
Author(s):  
Alexandra Stauffer ◽  
Angelo Tortora ◽  
Serge Marbacher ◽  
Julia Frey ◽  
Markus Gschwind ◽  
...  

2022 ◽  
Vol 3 (1) ◽  
pp. 101086
Author(s):  
Beatrice Malacrida ◽  
Oliver M.T. Pearce ◽  
Frances R. Balkwill

2022 ◽  
Vol 77 ◽  
pp. 102099
Author(s):  
Aivara Urbute ◽  
Christian Munk ◽  
Freja L. Sand ◽  
Federica Belmonte ◽  
Susanne K. Kjaer

MOJ Surgery ◽  
2108 ◽  
Vol 6 (4) ◽  
Author(s):  
Zaki Taissoun Aslan ◽  
Martin Granados Garcia ◽  
Kuauhyama Luna Ortiz ◽  
Francisco Javier Guerrero Huerta ◽  
Antonio Gomez Pedraza ◽  
...  

2022 ◽  
Vol 303 ◽  
pp. 114192
Author(s):  
Siyu Zhou ◽  
Xiaojian Liao ◽  
Shoupeng Li ◽  
Xiaodi Fang ◽  
Zhijie Guan ◽  
...  

ESMO Open ◽  
2022 ◽  
Vol 7 (1) ◽  
pp. 100364
Author(s):  
T. Al-Toubah ◽  
T. Halfdanarson ◽  
J. Gile ◽  
B. Morse ◽  
K. Sommerer ◽  
...  

Biomedicines ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 180
Author(s):  
Pil-Soo Sung ◽  
Chang-Min Kim ◽  
Jung-Hoon Cha ◽  
Jin-Young Park ◽  
Yun-Suk Yu ◽  
...  

Innate and adaptive immune responses are critically associated with the progression of fibrosis in chronic liver diseases. In this study, we aim to identify a unique immune-related gene signature representing advanced liver fibrosis and to reveal potential therapeutic targets. Seventy-seven snap-frozen liver tissues with various chronic liver diseases at different fibrosis stages (1: n = 12, 2: n = 12, 3: n = 25, 4: n = 28) were subjected to expression analyses. Gene expression analysis was performed using the nCounter PanCancer Immune Profiling Panel (NanoString Technologies, Seattle, WA, USA). Biological meta-analysis was performed using the CBS Probe PINGSTM (CbsBioscience, Daejeon, Korea). Using non-tumor tissues from surgically resected specimens, we identified the immune-related, five-gene signature (CHIT1_FCER1G_OSM_VEGFA_ZAP70) that reliably differentiated patients with low- (F1 and F2) and high-grade fibrosis (F3 and F4; accuracy = 94.8%, specificity = 91.7%, sensitivity = 96.23%). The signature was independent of all pathological and clinical features and was independently associated with high-grade fibrosis using multivariate analysis. Among these genes, the expression of inflammation-associated FCER1G, OSM, VEGFA, and ZAP70 was lower in high-grade fibrosis than in low-grade fibrosis, whereas CHIT1 expression, which is associated with fibrogenic activity of macrophages, was higher in high-grade fibrosis. Meta-analysis revealed that STAT3, a potential druggable target, highly interacts with the five-gene signature. Overall, we identified an immune gene signature that reliably predicts advanced fibrosis in chronic liver disease. This signature revealed potential immune therapeutic targets to ameliorate liver fibrosis.


2022 ◽  
Vol 11 (2) ◽  
pp. 449
Author(s):  
Sok-Sithikun Bun ◽  
Florian Asarisi ◽  
Nathan Heme ◽  
Fabien Squara ◽  
Didier Scarlatti ◽  
...  

Background: In patients with complete atrioventricular block (AVB), the prevalence and clinical characteristics of patients with pause-dependent AVB (PD-AVB) is not known. Our objective was to assess the prevalence of PD-AVB in a population of patients with complete (or high-grade) AVB. Methods: Twelve-lead electrocardiogram (ECG) and/or telemonitoring from patients admitted (from September 2020 to November 2021) for complete (or high-degree) AVB were prospectively collected at the University Hospital of Nice. The ECG tracings were analyzed by an electrophysiologist to determine the underlying mechanism of PD-AVB. Results: 100 patients were admitted for complete (or high-grade) AVB (men 55%; 82 ± 12 years). Arterial hypertension was present in 68% of the patients. Baseline QRS width was 117 ± 32 ms, and mean left ventricular ejection fraction was 56 ± 7%. Fourteen patients (14%) with PD-AVB were identified, and presented similar clinical characteristics in comparison with patients without PD-AVB, except for syncope (which was present in 86% versus 51% in the non-PD-AVB patients, p = 0.01). PD-AVB sequence was induced by: Premature atrial contraction (8/14), premature ventricular contraction (5/14), His extrasystole (1/14), conduction block in a branch (1/14), and atrial tachycardia termination (1/14). All patients with PD-AVB received a dual-chamber pacemaker during hospitalization. Conclusion: The prevalence of PD-AVB was 14%, and may be underestimated. PD-AVB episodes were more likely associated with syncope in comparison with patients without PD-AVB.


2022 ◽  
Vol 2022 ◽  
pp. 1-5
Author(s):  
Ying Dai ◽  
Weimin Chen ◽  
Xuanfu Xu ◽  
Jianqing Chen ◽  
Wenhui Mo ◽  
...  

Objective. To explore the factors affecting the adenoma risk level in patients with intestinal polyp and association. Methods. The clinical data of 3,911 patients with intestinal polyp treated in our hospital from January 2018 to January 2021 were retrospectively analyzed, all patients accepted the histopathological examination, their risk of suffering from adenoma was evaluated according to the results of pathological diagnosis, and relevant hazard factors affecting adenoma risk level in them were analyzed by multifactor logistic regression analysis. Results. The results of multifactor logistic analysis showed that male gender, age ≥60 years, number of polyps >3, diameter ≥2 cm, onset at colon, and physiologically tubulovillous adenoma were the hazard factors causing high-grade adenoma risk in patients with intestinal polyp. Conclusion. There are many risk factors causing high-grade adenoma in patients with intestinal polyp, and therefore, the screening for high-risk population shall be enhanced to reduce the potential of carcinomatous change in such patients.


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