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2022 ◽  
Vol 77 ◽  
pp. 102099
Aivara Urbute ◽  
Christian Munk ◽  
Freja L. Sand ◽  
Federica Belmonte ◽  
Susanne K. Kjaer

2022 ◽  
Vol 78 ◽  
pp. 110650
Alexandra Stauffer ◽  
Angelo Tortora ◽  
Serge Marbacher ◽  
Julia Frey ◽  
Markus Gschwind ◽  

2022 ◽  
Vol 3 (1) ◽  
pp. 101086
Beatrice Malacrida ◽  
Oliver M.T. Pearce ◽  
Frances R. Balkwill

Chantal A ten Kate ◽  
Anne-Fleur R L van Hal ◽  
Nicole S Erler ◽  
Michail Doukas ◽  
Suzan Nikkessen ◽  

SUMMARY Background Endoscopic surveillance of adults with esophageal atresia is advocated, but the optimal surveillance strategy remains uncertain. This study aimed to provide recommendations on appropriate starting age and intervals of endoscopic surveillance in adults with esophageal atresia. Methods Participants underwent standardized upper endoscopies with biopsies. Surveillance intervals of 3–5 years were applied, depending on age and histopathological results. Patient’s age and time to development of (pre)malignant lesions were calculated. Results A total of 271 patients with esophageal atresia (55% male; median age at baseline endoscopy 26.7 (range 15.6–68.5) years; colon interposition n = 17) were included. Barrett’s esophagus was found in 19 (7%) patients (median age 32.3 (17.8–56.0) years at diagnosis). Youngest patient with a clinically relevant Barrett’s esophagus was 20.9 years. Follow-up endoscopies were performed in 108 patients (40%; median follow-up time 4.6 years). During surveillance, four patients developed Barrett’s esophagus but no dysplasia or cancer was found. One 45-year-old woman with a colon interposition developed an adenoma with high-grade dysplasia which was radically removed. Two new cases of esophageal carcinoma were diagnosed in patients (55 and 66 years old) who were not under surveillance. One of them had been curatively treated for esophageal carcinoma 13 years ago. Conclusions This study shows that endoscopic screening of patients with esophageal atresia, including those with a colon interposition, can be started at 20 years of age. Up to the age of 40 years a surveillance interval of 10 years appeared to be safe. Endoscopic surveillance may also be warranted for patients after curative esophageal cancer treatment.

2022 ◽  
Vol 8 (1) ◽  
pp. 31-37
Vijay Kumar ◽  
Swayambhu Shubham ◽  
Satyendra Narayan Singh

Background: UTI constitute a major public health problem in India accounting 2nd most common infection next to respiratory tract infection. They are responsible for increasing treatment cost and significant morbidity.Aim:-To determine the incidence of UTI, evaluation of pathogens responsible and their antimicrobial susceptibility pattern in the population.Methods:Urine samples were collected from 300 patients attending the OPD Patna medical college, Patna during the period of 18 months (January 2017 to June 2018) Antimicrobial sensitivity testing was done for the bacterial isolates present in the sample by Kirby- Bauer disc diffusion method. Only those samples were taken into consideration which develops count equal to or greater than 1*105CFU/ml as indicated by Kass.Results:Out of 300 samples collected 146 (48.66%)) yielded bacterial growth. Out of 146 culture isolates E.Coli was the most common pathogen followed by klebsiella, CoNS and staphylococcus. Antibiotic sensitivity was performed on all the isolates. It was observed that highest sensitivity was 49.31% to amikacin, gentamycin (45.89%), nitrofurantoin (38.35%) meropenem (27.39%).Conclusions:It was observed that high grade of resistance to ampicillin, cotrimoxazole, ciprofloxacin, cefuroxime, chloramphenicol, cefotaxime, cefazolin, amoxicillin + clavulanic acid and gentamycin is present as a result of misuse or improper use of antibiotic in the community. Hence urine culture is necessary for the diagnostic screening of UTI before the treatment.

2022 ◽  
Vol 2022 ◽  
pp. 1-5
Ying Dai ◽  
Weimin Chen ◽  
Xuanfu Xu ◽  
Jianqing Chen ◽  
Wenhui Mo ◽  

Objective. To explore the factors affecting the adenoma risk level in patients with intestinal polyp and association. Methods. The clinical data of 3,911 patients with intestinal polyp treated in our hospital from January 2018 to January 2021 were retrospectively analyzed, all patients accepted the histopathological examination, their risk of suffering from adenoma was evaluated according to the results of pathological diagnosis, and relevant hazard factors affecting adenoma risk level in them were analyzed by multifactor logistic regression analysis. Results. The results of multifactor logistic analysis showed that male gender, age ≥60 years, number of polyps >3, diameter ≥2 cm, onset at colon, and physiologically tubulovillous adenoma were the hazard factors causing high-grade adenoma risk in patients with intestinal polyp. Conclusion. There are many risk factors causing high-grade adenoma in patients with intestinal polyp, and therefore, the screening for high-risk population shall be enhanced to reduce the potential of carcinomatous change in such patients.

Medicine ◽  
2022 ◽  
Vol 101 (2) ◽  
pp. e28490
Huimin Bai ◽  
Fang Yuan ◽  
Bing Liang ◽  
Hengzi Sun ◽  
Yutao Gao ◽  

2022 ◽  
Vol 1 (1) ◽  
pp. 47-53
Meiliana Nur Fitriani ◽  
Budi Hendrawan ◽  
Mohammad Fahmi Nugraha ◽  
Yopa Taufik Saleh

This Community Partnership Program (PKM) aims to increase primary students’ understanding of the dangers of Covid 19 and educate them on how to prevent it through correct health protocols and being able to implement a healthy lifestyle. The targets of this program are high grade of primary students, namely grade 4, grade 5, and grade 6. The method used in this education is storytelling in an interactive online style via zoom platform. Stories are conveyed in English with simple language and sentences to make them easier to understand, besides that the delivery is combined with Indonesian so that children understand the meaning and are able to imitate certain sentences and movements well. The implementation of this program makes students enthusiastic and excited, especially using English. The students feel cooler when they listen to stories and speak English. Children enthusiastically mimic, sing and perform healthy protocol movements in interesting ways. Thus, children are able to understand the contents of the stories and values ??that are conveyed, so that they are able to apply them to new good habits in the era of new normal life. As conclusion, the storytelling method is able to provide a good understanding of the Covid 19 pandemic for children, so that awareness emerges to apply health protocols in their daily life

2022 ◽  
Vol 17 (1) ◽  
Vladimír Šámal ◽  
Tomáš Jirásek ◽  
Vít Paldus ◽  
Igor Richter ◽  
Ondřej Hes

Abstract Background Yolk sac tumor (YST) is a germ cell tumor. It is primarily located in the gonads but can also occur extragonadally (extragonadal yolk sac tumor - EGYST), most commonly in the pelvis, retroperitoneum or mediastinum. Only a few YSTs of the urachus have been described. Case report We present a rare case report of a 37-year-old male with episodes of macroscopic hematuria. The histological specimen obtained by transurethral resection showed a solid, and in some parts papillary infiltrative, high-grade tumor with numerous areas of marked nuclear atypia and clear invasion between the detrusor bundles. Glandular pattern has been observed in only minority of the tumor. Immunohistochemistry showed significant positivity for GPC3, SALL4 and cytokeratins AE1/AE3, while KRT7 and GATA3 were negative. We concluded that the biopsy findings were consistent with urothelial carcinoma with infrequent YST differentiation. In definitive surgical specimens we found a malignant epithelial, glandular and cystically arranged tumor of germinal appearance arising from urachus. The surrounding urothelium was free of invasive or in situ tumor changes. We reclassified the tumor as a urachal YST. Conclusion EGYST was suspected because glandular and hepatoid structures were found, but the presence of these structures should be verified by immunohistochemistry.

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