One-Pot Synthesis of 3-(1,2,3,4-Tetrahydroisoquinolin-1-yl)-isoquinolin-1(2H)-ones by Sequential DEAD-Promoted Oxidative Ugi/Wittig Reaction Starting from Phosphonium Salt Precursors
A new one-pot Synthesis of 3-(1,2,3,4-tetrahydroisoquinolin-1-yl)- isoquinolin-1(2H)-ones by DEAD-promoted oxidative Ugi/Wittig reaction was developed. The sequential reactions of (2-carboxybenzyl)triphenylphosphonium salts, isocyanides and N-aryl-1,2,3,4-tetrahydroisoquinolines produced 3-(1,2,3,4-tetrahydroisoquinolin-1-yl)- isoquinolin-1(2H)-ones in moderate to good overall yields in the presence of DEAD and Et3N.
2007 ◽
Vol 72
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pp. 9523-9532
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2016 ◽
Vol 81
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pp. 1263-1268
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pp. 4213-4217
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pp. 6488-6490
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