Synthesis of Isoquinoline-1,3(2H,4H)-diones by Visible-light-mediated the Cyclization of Acryloylbenzamides with Alkyl Boronic Acids, Arylsulfonylhydrazides and Oxime Esters

An efficient visible-light-mediated tandem reaction of acryloylbenzamides with alkyl boronic acids, arylsulfonylhydrazides and oxime esters is developed. The reaction proceeds the radical addition and cyclization to give various isoquinoline-1,3(2H,4H)-diones in satisfactory yields under mild conditions, which provides a good opportunity to discover new meaningful bioactive compounds.

RhodiumIII-Catalyzed Successive Csp2‒H and Csp2‒Csp2 Bond Activation of Aryl Oximes: Synthetic and Mechanistic Studies

Merging selective C–H cleavage with C–C cleavage in a tandem reaction has been a practical strategy that permits skeletal diversification from simple raw materials. Herein, we describe a rhodiumIII-catalyzed redox-neutral...

Metal-Free Tandem Dehydrogenative α-Arylation Reaction of Propargylic Alcohols with 2-Alkynylbenzaldoximes toward the Synthesis of α-(4-Bromo-isoquinolin-1-yl)-propenone Skeletons

A tandem reaction of 2-alkynylbenzaldoximes with propargylic alcohols has been developed for the synthesis of α-(4-bromo-isoquinolin-1-yl)-propenones. Employing 2-alkynylbenzaldoximes as a precursor in the presence of Br2 generates 4-Bromo-isoquinoline-N-oxides. Subsequently, dehydroxylation...