Determination of absolute configuration of chiral molecules using vibrational optical activity

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
Y He ◽  
B Wang ◽  
RK Dukor ◽  
LA Nafie
Keyword(s):  
Optical Activity ◽  
Absolute Configuration ◽  
Chiral Molecules ◽  
Determination Of Absolute Configuration

scholarly journals Vibrational Circular Dichroism: A New Tool for the Solution-State Determination of the Structure and Absolute Configuration of Chiral Natural Product Molecules

2008 ◽  
Vol 3 (3) ◽  
pp. 1934578X0800300 ◽  
Author(s):  
Laurence A. Nafie
Keyword(s):  
Circular Dichroism ◽  
Natural Product ◽  
Absolute Configuration ◽  
Vibrational Circular Dichroism ◽  
Chiral Molecules ◽  
Solution State ◽  
X Ray Crystallography ◽  
Determination Of Absolute Configuration ◽  
Circular Dichroïsm

Vibrational circular dichroism (VCD) has been used in recent years to determine the absolute configuration of a number of natural product chiral molecules. In this brief review, these applications will be described and the methodology of VCD determination of absolute configuration (AC) will be explained. The principal advantages of VCD versus X-ray crystallography for absolute configuration determination are: 1) only solution-state samples are needed and therefore single crystals are not required, 2) high enantiomeric sample purity is not required, 3) high chemical purity is not required as long as impurities are not chiral and 4) solution-state conformations are obtained as an extra feature of the AC determination.

Solid State Optical Activity of Dichalcogenides:  Isolation by Chiral Crystallization and Determination of Absolute Configuration

2001 ◽  
Vol 3 (23) ◽  
pp. 3639-3641 ◽  
Author(s):  
Toshio Shimizu ◽  
Hiromi Isono ◽  
Masanori Yasui ◽  
Fujiko Iwasaki ◽  
Nobumasa Kamigata
Keyword(s):  
Solid State ◽  
Optical Activity ◽  
Absolute Configuration ◽  
Determination Of Absolute Configuration

Prismatomerin, a New Iridoid fromPrismatomeristetrandra. Structure Elucidation, Determination of Absolute Configuration, and Cytotoxicity

2007 ◽  
Vol 70 (8) ◽  
pp. 1339-1343 ◽  
Author(s):  
Karsten Krohn ◽  
Dietmar Gehle ◽  
Sujit Kumar Dey ◽  
Nilufar Nahar ◽  
Mohammed Mosihuzzaman ◽  
...  
Keyword(s):  
Absolute Configuration ◽  
Structure Elucidation ◽  
Determination Of Absolute Configuration
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