Copper-Catalyzed Asymmetric Synthesis of Homoallylic Alcohols via Borylation

Synfacts ◽  
2018 ◽  
Vol 14 (09) ◽  
pp. 0938
Keyword(s):  
Asymmetric Synthesis ◽  
Homoallylic Alcohols

Catalytic asymmetric synthesis of homoallylic alcohols

1993 ◽  
Vol 115 (15) ◽  
pp. 7001-7002 ◽  
Author(s):  
Anna Luisa Costa ◽  
Maria Giulia Piazza ◽  
Emilio Tagliavini ◽  
Claudio Trombini ◽  
Achille Umani-Ronchi
Keyword(s):  
Asymmetric Synthesis ◽  
Catalytic Asymmetric Synthesis ◽  
Homoallylic Alcohols ◽  
Catalytic Asymmetric

Asymmetric synthesis of disubstituted C-silylated homoallylic alcohols from lithiated allylic and vinylic sulfoximines

1995 ◽  
Vol 36 (41) ◽  
pp. 7433-7436 ◽  
Author(s):  
Hans-Joachim Gais ◽  
Harald Müller ◽  
Jürgen Decker ◽  
Rüdiger Hainz
Keyword(s):  
Asymmetric Synthesis ◽  
Homoallylic Alcohols

scholarly journals Asymmetric Synthesis of Homoallylic Alcohols Featuring Vicinal Tetrasubstituted Carbon Centers via Dual Pd/Photoredox Catalysis

2021 ◽  
Author(s):  
Sijing Xue ◽  
Bart Limburg ◽  
Debasish Ghorai ◽  
Jordi Benet Buchholz ◽  
Arjan. W. Kleij
Keyword(s):  
Asymmetric Synthesis ◽  
Allylic Alkylation ◽  
Cyclic Carbonates ◽  
Photoredox Catalysis ◽  
Reaction Conditions ◽  
Carbon Centers ◽  
Homoallylic Alcohols ◽  
Target Molecules ◽  
The Creation

Dual palladium/photoredox-catalysis provides an effective method for the asymmetric synthesis of vicinal a,b-tri/tetra- or a,b-tetra-substituted homoallylic alcohols. Regio- and enantioselective decarboxylative allylic alkylation of vinyl cyclic carbonates is reported using Hantzsch type esters as radical precursors. The developed methodology combines the use of versatile and accessible reagents and can be operated under mild reaction conditions giving the target molecules in appreciable to good yields, high branch-selectivity and appreciable enantiomeric ratios of up to 94:6. This protocol marks a rare example of the use of prochiral electrophiles for the creation of vicinal congested carbon centers.

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