We
report a three-component olefin reductive dicarbofunctionalization for
constructing densely functionalized alkylborates, specifically,
nickel-catalyzed reductive dialkylation and alkylarylation of vinyl boronates
with a variety of alkyl bromides and aryl iodides. This reaction exhibits good
coupling efficiency and excellent functional group compatibility, providing
convenient access to the late-stage modification of complex natural products
and drug molecules. Combined with versatile alkylborate transformations, this
reaction could also find applications in the modular and convergent synthesis
of complex, densely functionalized compounds.
Nickel-Catalyzed Three-Component Olefin Reductive Dicarbofunctionalization to Access Highly Functionalized Alkylborates
