coupling efficiency
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2022 ◽  
Vol 11 (1) ◽  
Author(s):  
Zhiyue Zhou ◽  
Zefeng Wang ◽  
Wei Huang ◽  
Yulong Cui ◽  
Hao Li ◽  
...  

AbstractFibre lasers operating at the mid-IR have attracted enormous interest due to the plethora of applications in defence, security, medicine, and so on. However, no continuous-wave (CW) fibre lasers beyond 4 μm based on rare-earth-doped fibres have been demonstrated thus far. Here, we report efficient mid-IR laser emission from HBr-filled silica hollow-core fibres (HCFs) for the first time. By pumping with a self-developed thulium-doped fibre amplifier seeded by several diode lasers over the range of 1940–1983 nm, narrow linewidth mid-IR emission from 3810 to 4496 nm has been achieved with a maximum laser power of about 500 mW and a slope efficiency of approximately 18%. To the best of our knowledge, the wavelength of 4496 nm with strong absorption in silica-based fibres is the longest emission wavelength from a CW fibre laser, and the span of 686 nm is also the largest tuning range achieved to date for any CW fibre laser. By further reducing the HCF transmission loss, increasing the pump power, improving the coupling efficiency, and optimizing the fibre length together with the pressure, the laser efficiency and output power are expected to increase significantly. This work opens new opportunities for broadly tunable high-power mid-IR fibre lasers, especially beyond 4 μm.


2022 ◽  
Vol 8 ◽  
Author(s):  
Hualiang Zhao ◽  
Chuanxin Zhang ◽  
Jiajie He ◽  
Ying Li ◽  
Boyi Li ◽  
...  

We demonstrate the nondestructive evaluation by means of directional ultrasound emitted from a planar metasurface. The ultrasound metasurface is designed to generate the collimated and directional ultrasound efficiently in a planar configuration, which is endowed with the full-2π-range phase manipulation ability and high transmittance up to 80%. We employ the directional emission based on the ultrasound metasurface to innovate the traditional nondestructive evaluation methods, benefited from the freely controlled directivity and the superior fitness to sample surface of the planar metasurface. Merits of this innovative application are evidenced by the remarkable accuracy (higher than 98%) in the thickness evaluation, and precise detection (accuracy higher than 96%) of the special defect inside the V-shaped workpiece which is intractable to be inspected conventionally. The implementation of the metasurface-based directional ultrasound emission in the nondestructive evaluation bears the advantages of high coupling efficiency, superior fitness, high accuracy, and applicability to special defect, providing new solutions to the challenges in conventional defect detection and promotes the development in the nondestructive evaluation applications.


Crystals ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 70
Author(s):  
Fan Yang ◽  
Hong Fang ◽  
Huangpu Han ◽  
Bingxi Xiang

In this research, a vertical silicon nitride strip-loaded grating coupler on lithium niobate thin film was proposed, designed, and simulated. In order to improve the coupling efficiency and bandwidth, the parameters such as the SiO2 cladding layer thickness, grating period, duty cycle, fiber position, and fiber angle were optimized and analyzed. The alignment tolerances of the grating coupler parameters were also calculated. The maximum coupling efficiency and the −3 dB bandwidth were optimized to 33.5% and 113 nm, respectively. In addition, the grating coupler exhibited a high alignment tolerance.


2022 ◽  
Author(s):  
Gabriella L. Robertson ◽  
Stellan Riffle ◽  
Mira Patel ◽  
Andrea Marshall ◽  
Heather Beasley ◽  
...  

Mitochondria and peroxisomes are both dynamic signaling organelles that constantly undergo fission. While mitochondrial fission is known to coordinate cellular metabolism, proliferation, and apoptosis, the physiological relevance of peroxisome dynamics and the implications for cell fate are not fully understood. DRP1 (dynamin-related protein 1) is an essential GTPase that executes both mitochondrial and peroxisomal fission. Patients with de novo heterozygous missense mutations in the gene that encodes DRP1, DNM1L, present with encephalopathy due to defective mitochondrial and peroxisomal fission (EMPF1). EMPF1 is a devastating neurodevelopmental disease with no effective treatment. To interrogate the mechanisms by which DRP1 mutations cause cellular dysfunction, we utilized human-derived fibroblasts from patients with mutations in DRP1 who present with EMPF1. As expected, patient cells display elongated mitochondrial morphology and lack of fission. Patient cells display a lower coupling efficiency of the electron transport chain, increased proton leak, and upregulation of glycolysis. In addition to these metabolic abnormalities, mitochondrial hyperfusion results in aberrant cristae structure and hyperpolarized mitochondrial membrane potential, both of which are tightly linked to the changes in metabolism. Peroxisome structure is also severely elongated in patient cells and results in a potential functional compensation of fatty acid oxidation. Understanding the mechanism by which DRP1 mutations cause these metabolic changes will give insight into the role of mitochondrial dynamics in cristae maintenance and the metabolic capacity of the cell, as well as the disease mechanism underlying EMPF1.


2022 ◽  
Vol 68 ◽  
pp. 102766
Author(s):  
Shengqiang Lu ◽  
Fan Zhang ◽  
Cong Xu ◽  
Ji'an Duan

ChemSusChem ◽  
2021 ◽  
Author(s):  
Shuaiqi Meng ◽  
Yu Ji ◽  
Luo Liu ◽  
Mehdi D. Davari ◽  
Ulrich Schwaneberg

Author(s):  
Nishant Verma ◽  
Robert D. Graham ◽  
Jonah Mudge ◽  
James K. Trevathan ◽  
Manfred Franke ◽  
...  

Minimally invasive neuromodulation technologies seek to marry the neural selectivity of implantable devices with the low-cost and non-invasive nature of transcutaneous electrical stimulation (TES). The Injectrode® is a needle-delivered electrode that is injected onto neural structures under image guidance. Power is then transcutaneously delivered to the Injectrode using surface electrodes. The Injectrode serves as a low-impedance conduit to guide current to the deep on-target nerve, reducing activation thresholds by an order of magnitude compared to using only surface stimulation electrodes. To minimize off-target recruitment of cutaneous fibers, the energy transfer efficiency from the surface electrodes to the Injectrode must be optimized. TES energy is transferred to the Injectrode through both capacitive and resistive mechanisms. Electrostatic finite element models generally used in TES research consider only the resistive means of energy transfer by defining tissue conductivities. Here, we present an electroquasistatic model, taking into consideration both the conductivity and permittivity of tissue, to understand transcutaneous power delivery to the Injectrode. The model was validated with measurements taken from (n = 4) swine cadavers. We used the validated model to investigate system and anatomic parameters that influence the coupling efficiency of the Injectrode energy delivery system. Our work suggests the relevance of electroquasistatic models to account for capacitive charge transfer mechanisms when studying TES, particularly when high-frequency voltage components are present, such as those used for voltage-controlled pulses and sinusoidal nerve blocks.


Biomolecules ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1880
Author(s):  
Hristo Zlatev ◽  
Charlotte von Horn ◽  
Thomas Minor

Background: Warm reperfusion after previous cold storage has been shown to have a negative impact on mitochondrial function of organ grafts. Here, we wanted to investigate whether a more controlled warming up of the cold graft by ex vivo machine perfusion with gradually elevated temperature from cold to normothermia (including comparison of two warming up protocols) prior to implantation would be effective in preventing mitochondrial dysfunction upon reperfusion. Methods: All experiments were conducted on porcine kidneys retrieved 15 min after cardiac arrest. After 18 h of cold storage in HTK solution (CS, n = 6), kidneys (n = 6) were subjected to 2 h of reconditioning machine perfusion starting with a hypothermic period followed by a gradual increase in perfusion temperature up to 35 °C (controlled oxygenated rewarming—COR). For a second group (n = 6), the slow warming up was begun instantly after connecting the graft onto the machine (iCOR). Functional recovery of all grafts was then observed upon normothermic reperfusion in vitro. At the conclusion of the experiments, tissue specimens were taken for immediate isolation and analysis of renal mitochondria. Results: COR resulted in a significantly and more than 3-fold increased glomerular filtration rate upon reperfusion, along with a significant higher tubular sodium reabsorption and lesser loss of glucose in comparison to the controls. Enzyme release (AST) was also massively reduced during the reperfusion period. Specific analysis at the mitochondrial level revealed significantly better coupling efficiency and spare respiratory capacity in the COR group compared to the cold storage group. Interestingly, additional experiments revealed that the omission of a hypothermic perfusion period did not deteriorate any of the results after COR, provided that the instant temperature increase from 10 to 35 °C was effectuated in the same controlled manner. Conclusion: Controlled rewarming after extended cold preservation effectively improves mitochondrial recovery upon reperfusion and early functional outcome of kidney grafts.


2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Rami A. Wahsheh

Hybrid integration of dielectric and plasmonic waveguides is necessary to reduce the propagation losses due to the metallic interactions and support of nanofabrication of plasmonic devices that deal with large data transfer. In this paper, we propose a direct yet efficient, very short air-slot coupler (ASC) of a length of 36 nm to increase the coupling efficiency between a silicon waveguide and a silver-air-silver plasmonic waveguide. Our numerical simulation results show that having the ASC at the interface makes the fabrication process much easier and ensures that light couples from a dielectric waveguide into and out of a plasmonic waveguide. The proposed coupler works over a broad frequency range achieving a coupling efficiency of 86% from a dielectric waveguide into a metal-dielectric-metal (MDM) plasmonic waveguide and 68% from a dielectric waveguide to an MDM plasmonic waveguide and back into another dielectric waveguide. In addition, we show that even if there are no high-precision fabrication techniques, light couples from a conventional dielectric waveguide (CDW) into an MDM plasmonic waveguide as long as there is an overlap between the CDW and ASC, which reduces the fabrication process tremendously. Our proposed coupler has an impact on the miniaturization of ultracompact nanoplasmonic devices.


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