The neural correlates of set-shifting, concept formation and working memory during performance of the Wisconsin Card Sorting Test - a fMRI study

2004 ◽  
Vol 31 (S 1) ◽  
Author(s):  
C Lie ◽  
K Specht ◽  
K Zilles ◽  
GR Fink



2021 ◽  
Vol 15 ◽  
Author(s):  
Mariasole Ciampoli ◽  
Diego Scheggia ◽  
Francesco Papaleo

Adolescence is a developmental period crucial for the maturation of higher-order cognitive functions. Indeed, adolescence deficits in executive functions are strong predictors of increased vulnerability to several mental disabilities later in life. Here, we tested adolescent mice in a fully-automated attentional set-shifting task equivalent to the humans’ Wisconsin Card Sorting Test (WCST) and the Cambridge Neuropsychological Test Automated Battery Intra-/Extra-Dimensional set-shift task (ID/ED). Compared to an adult, adolescent mice required more time to complete the task (≈16 days), and a higher percentage failed to finish the entire task. Nevertheless, adolescent mice completing this demanding task showed an increased effort in solving the extradimensional shift stage (EDS) compared to previous stages. Moreover, we found that this paradigm can be used to detect early cognitive dysfunctions in adolescent genetically modified mice. Thus, this automatic paradigm provides a further tool to assess attentional control in adolescent mice, and the development of dysfunctional executive functions from adolescence to adulthood.



2000 ◽  
Vol 38 (10) ◽  
pp. 1342-1355 ◽  
Author(s):  
Francisco Barceló ◽  
Juan M Muñoz-Céspedes ◽  
Miguel A Pozo ◽  
Francisco J Rubia


1995 ◽  
Vol 15 (1-2) ◽  
pp. 117-118
Author(s):  
J. Gold ◽  
C. Carpenter ◽  
C. Randolph ◽  
T. Goldberg ◽  
D. Weinberger


2001 ◽  
Vol 251 (2) ◽  
pp. 66-71 ◽  
Author(s):  
Stefan Riehemann ◽  
Hans-Peter Volz ◽  
Peggy Stützer ◽  
Stefan Smesny ◽  
Christian Gaser ◽  
...  


2008 ◽  
Vol 102 (1-3) ◽  
pp. 91
Author(s):  
Patricia Ohrmann ◽  
Andreas Wilmsmeier ◽  
Jochen Bauer ◽  
Ansgar Siegmund ◽  
Thomas Suslow ◽  
...  


2005 ◽  
Vol 146 (2) ◽  
pp. 165-173 ◽  
Author(s):  
Tara L. Moore ◽  
Ronald J. Killiany ◽  
James G. Herndon ◽  
Douglas L. Rosene ◽  
Mark B. Moss


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