Desipramine Induces Cardiac Beta-Adrenergic Sensitivity Decrease in Major Depressed Patients without Relationship to Therapeutic Response

Beta-adrenergic-mediated cyclic AMP accumulation was reduced in lymphocytes obtained from depressed patients from that observed in an age- and sex-matched group of control subjects. Among the depressed patients, those not responding to treatment showed significantly lower pretreatment responses to isoproterenol compared with patients who exhibited significant clinical improvement during antidepressant treatment. Late-night (terminal) insomnia was significantly associated with the blunted response to beta-adrenergic stimulation. In depressed patients with the lowest isoproterenol response, the effect of forskolin (which acts distal to the receptor and directly stimulates the catalytic subunit) on cyclic AMP accumulation was also significantly decreased. This suggests that post-receptor modulations of signal amplification also play a role in the reduced response to beta-adrenergic stimulation in depression.

Download Full-text

Does G2677T Polymorphism of the MDR1 Gene Make a Difference in the Therapeutic Response to Paroxetine in Depressed Patients in a Slovakian Population?

Medical Science Monitor ◽

10.12659/msm.907434 ◽

2018 ◽

Vol 24 ◽

pp. 3136-3145 ◽

Cited By ~ 1

Author(s):

Zuzana Vancova ◽

Martina Cizmarikova ◽

Jozef Dragasek ◽

Silvia Zofcakova ◽

Peter Kolarcik ◽

...

Keyword(s):

Therapeutic Response ◽

Mdr1 Gene ◽

Depressed Patients

Download Full-text

The relationship between the change in thyrotropin response to trh and therapeutic response to desipramine (DMI) in depressed patients

Biological Psychiatry ◽

10.1016/0006-3223(89)91904-5 ◽

1989 ◽

Vol 25 (7) ◽

pp. A206-A207 ◽

Cited By ~ 2

Author(s):

Andrew Winokur ◽

Jay D. Amsterdam ◽

Neil Berwish ◽

Jennifer L. Phillips ◽

Greg Maislin

Keyword(s):

Therapeutic Response ◽

Depressed Patients ◽

The Relationship

Download Full-text

Platelet MAO inhibition, urinary MHPG, and leukocyte beta-adrenergic receptors in depressed patients treated with phenelzine

American Journal of Psychiatry ◽

10.1176/ajp.147.10.1318 ◽

1990 ◽

Vol 147 (10) ◽

pp. 1318-1321 ◽

Cited By ~ 4

Keyword(s):

Adrenergic Receptors ◽

Beta Adrenergic Receptors ◽

Beta Adrenergic ◽

Mao Inhibition ◽

Depressed Patients ◽

Platelet Mao

Download Full-text

Mirtazapine Treatment of a Severe Depressive Episode and Resolution of Elevated Inflammatory Markers

Case Reports in Psychiatry ◽

10.1155/2013/697872 ◽

2013 ◽

Vol 2013 ◽

pp. 1-3

Author(s):

Shahzad M. Alikhan ◽

Jessica A. Lee ◽

Luiz Dratcu

Keyword(s):

Immune System ◽

Depressive Episode ◽

Mode Of Action ◽

Inflammatory Markers ◽

Therapeutic Response ◽

Inflammatory Responses ◽

Medical Comorbidity ◽

Antidepressant Response ◽

Depressed Patients

Depression has been shown to be associated with systemic inflammatory activity and the mode of action of several antidepressants appears to involve immunomodulation. Effects on immune system activity have also recently been observed in correlation with therapeutic response to mirtazapine in cardiac patients with depression, but no study has yet examined these effects in otherwise physically healthy depressed patients treated with mirtazapine. This report describes an association between a clinical antidepressant response and a decrease in markers of systemic inflammation observed during pharmacotherapy with mirtazapine in a severely depressed but physically well patient. This observation adds to the evidence that changes in inflammatory responses may be implicated in the mode of action of antidepressants. Further studies of antidepressant responses to mirtazapine and levels of inflammatory markers in depressed patients without medical comorbidity can help elucidate the role of the immune system in the pathophysiology of depression, and hence contribute to the development of novel antidepressant therapies.

Download Full-text