Malignant Melanoma in Patients Treated for Psoriasis with Methoxsalen (Psoralen) and Ultraviolet A Radiation (PUVA)

Erythema is a readily visible, often painful, natural phenomenon indicative of prolonged cutaneous exposure to ultraviolet (UV) radiation in the UVB range. As a result, early sunscreens were designed to provide adequate protection from UVB radiation. However, the continuous rise in the melanoma incidence rate alludes to the existence of an established photocarcinogen from which we are not well protected. Recently, scientists have been evaluating the photodamaging effects caused by wavelengths other than UVB. They have presented evidence that suggests that UVA exposure poses a greater hazard than previously acknowledged. For this reason, more emphasis must be placed on the development of broad-spectrum sunscreens providing adequate UVA and UVB protection. Additionally, regular sunscreen application must be advocated, proactive sun-protective practices must be implemented, and greater public awareness of the harmful effects of UVA and UVB radiation must be improved on, with the hope of decreasing the rate of cutaneous malignant melanoma.

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Laser radiation for metastatic malignant melanoma

JAMA ◽

10.1001/jama.195.5.393 ◽

1966 ◽

Vol 195 (5) ◽

pp. 393-394 ◽

Cited By ~ 2

Author(s):

P. E. McGuff

Keyword(s):

Laser Radiation ◽

Malignant Melanoma ◽

Metastatic Malignant Melanoma

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Ultrastructural changes in murine lymphoma cells exposed to ultraviolet-A radiation

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010008482x ◽

1991 ◽

Vol 49 ◽

pp. 104-105

Author(s):

Delma P. Thomas ◽

Dianne E. Godar

Keyword(s):

Medical Devices ◽

Blood Cells ◽

White Blood Cells ◽

Consumer Products ◽

Ultrastructural Changes ◽

Ultraviolet A ◽

Uv Spectrum ◽

Lymphoma Cells ◽

Murine Lymphoma ◽

Transmission Electron

Ultraviolet radiation (UVR) from all three waveband regions of the UV spectrum, UVA (320-400 nm), UVB (290-320 nm), and UVC (200-290 nm), can be emitted by some medical devices and consumer products. Sunlamps can expose the blood to a considerable amount of UVR, particularly UVA and/or UVB. The percent transmission of each waveband through the epidermis to the dermis, which contains blood, increases in the order of increasing wavelength: UVC (10%) < UVB (20%) < UVA (30%). To investigate the effects of UVR on white blood cells, we chose transmission electron microscopy to examine the ultrastructure changes in L5178Y-R murine lymphoma cells.

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