Activated charcoal alone and followed by whole-bowel irrigation in preventing the absorption of sustained-release drugs

2001 ◽  
Vol 70 (3) ◽  
pp. 255-260 ◽  
Author(s):  
O Lapatto-Reiniluoto
Keyword(s):  
Sustained Release ◽  
Activated Charcoal ◽  
Whole Bowel Irrigation

Ondansetron in the Treatment of Intractable Nausea Associated with Theophylline Toxicity

1993 ◽  
Vol 27 (5) ◽  
pp. 584-585 ◽  
Author(s):  
Therese A. Sage ◽  
William N. Jones ◽  
Richard F. Clark
Keyword(s):  
Sustained Release ◽  
Activated Charcoal ◽  
Antiemetic Therapy ◽  
Clinical Failure ◽  
Multiple Doses ◽  
Whole Bowel Irrigation ◽  
Sustained Release Theophylline

OBJECTIVE: To report the efficacy of ondansetron in the treatment of a patient poisoned with theophylline. PATIENT: A 36-year-old man who ingested 6 g of sustained-release theophylline. INTERVENTION: Ondansetron 8 mg intravenously after clinical failure of other antiemetics. RESULTS: Subjective relief of nausea within minutes, enabling the patient to tolerate multiple doses of activated charcoal and whole bowel irrigation. CONCLUSIONS: Ondansetron may offer an alternative to present antiemetic therapy in the poisoned patient.

Theophylline Toxicokinetics

1993 ◽  
Vol 6 (2) ◽  
pp. 57-62 ◽  
Author(s):  
Frank P. Paloucek
Keyword(s):  
Sustained Release ◽  
Activated Charcoal ◽  
Simple Calculation ◽  
Serum Theophylline ◽  
Charcoal Hemoperfusion ◽  
Theophylline Intoxication

Toxicokinetics, the application of pharmacokinetic principles in the assessment and management of the poisoned patient, is demonstrated for theophylline poisonings. Theophylline intoxication and its treatment is briefly reviewed and differentiated for acute or chronic etiologies. A toxicokinetic strategy for the simple calculation and evaluation of serum theophylline concentrations following sustained-release products overdosage is presented. A toxicokinetic basis for treatment durations of activated charcoal, hemoperfusion, or hemodialysis is described. Common toxicokinetic factors responsible for presentation with chronic theophylline intoxication are mentioned.

scholarly journals Advances in poison management

1996 ◽  
Vol 42 (8) ◽  
pp. 1361-1366 ◽  
Author(s):  
M J Bayer ◽  
C McKay
Keyword(s):  
Activated Charcoal ◽  
Whole Bowel Irrigation

Abstract This article advances the most current concepts in the management of poisoned patients including the use of ipecac, lavage, activated charcoal, whole-bowel irrigation, and specific antidotes. The benefits vs the risks of each of these procedures are reviewed.

Whole-bowel irrigation versus activated charcoal in sorbitol for the ingestion of modified-release pharmaceuticals

1989 ◽  
Vol 46 (3) ◽  
pp. 264-271 ◽  
Author(s):  
Lorrie A Kirshenbaum ◽  
Susan C Mathews ◽  
Daniel S Sitar ◽  
Milton Tenenbein
Keyword(s):  
Activated Charcoal ◽  
Modified Release ◽  
Whole Bowel Irrigation

Prevention of drug absorption in simulated theophylline overdose

1995 ◽  
Vol 14 (2) ◽  
pp. 170-174 ◽  
Author(s):  
Neil A. Minton ◽  
Edward Glucksman ◽  
John A. Henry
Keyword(s):  
Sustained Release ◽  
Healthy Volunteers ◽  
Drug Absorption ◽  
Activated Charcoal ◽  
Gastric Lavage ◽  
First Line ◽  
Sustained Release Theophylline ◽  
The Mean ◽  
Theophylline Absorption ◽  
First Line Treatment

1 The effects of emesis, gastric lavage and oral activated charcoal on theophylline absorption were compared in healthy volunteers. 2 One of four regimes (ipecacuanha-induced emesis, gas tric lavage, oral activated charcoal and no treatment) was randomly chosen one hour after a simulated over dose with sustained-release theophylline on four sepa rate occasions in twelve healthy volunteers. 3 Syrup of ipecacuanha produced emesis in all twelve volunteers but only seven vomited any tablets. Gastric lavage yielded tablets in only one volunteer. 4 The mean systemic availabilities (areas under the con centration-time curves relative to control) of theo phylline for ipecacuanha-induced emesis, gastric lavage and charcoal, were 107.1%, 101.1% and 16.9%, respectively. 5 Oral activated charcoal was thus highly effective, while gastric lavage and emesis were ineffective in pre venting theophylline absorption. Activated charcoal is potentially the most effective first-line treatment for acute overdosage with sustained-release theophylline tablets.

Theophylline Desorption From Activated Charcoal Caused By Whole Bowel Irrigation Solution1

1991 ◽  
Vol 29 (2) ◽  
pp. 191-201 ◽  
Author(s):  
Robert S. Hoffman ◽  
William K. Chiang ◽  
Mary Ann Howland ◽  
Richard S. Weisman ◽  
Lewis R. Goldfrank
Keyword(s):  
Activated Charcoal ◽  
Whole Bowel Irrigation
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