The influence of arachidonic acid metabolites on leukocyte activation and skeletal muscle injury after ischemia and reperfusion

1991 ◽  
Vol 14 (4) ◽  
pp. 549-556 ◽  
Author(s):  
Adelin H. Albert ◽  
Robert A. Cambria ◽  
Robert J. Anderson ◽  
George J. Dikdan ◽  
Thomas W. Lysz
Keyword(s):  
Skeletal Muscle ◽  
Arachidonic Acid ◽  
Muscle Injury ◽  
Ischemia And Reperfusion ◽  
Leukocyte Activation ◽  
Skeletal Muscle Injury ◽  
Arachidonic Acid Metabolites ◽  
Acid Metabolites

scholarly journals Ischemic pre and postconditioning in skeletal muscle injury produced by ischemia and reperfusion in rats

2013 ◽  
Vol 28 (6) ◽  
pp. 441-446 ◽  
Author(s):  
José Alves Lintz ◽  
Marcelo Bellini Dalio ◽  
Edwaldo Edner Joviliano ◽  
Carlos Eli Piccinato
Keyword(s):  
Skeletal Muscle ◽  
Muscle Injury ◽  
Ischemia And Reperfusion ◽  
Skeletal Muscle Injury

Static contraction increases arachidonic acid levels in gastrocnemius muscles of cats

1989 ◽  
Vol 66 (6) ◽  
pp. 2721-2724 ◽  
Author(s):  
D. M. Rotto ◽  
K. D. Massey ◽  
K. P. Burton ◽  
M. P. Kaufman
Keyword(s):  
Skeletal Muscle ◽  
Arachidonic Acid ◽  
Hind Limb ◽  
Pressor Response ◽  
Cyclooxygenase Activity ◽  
Hindlimb Muscle ◽  
Static Contraction ◽  
Arachidonic Acid Metabolites ◽  
Acid Metabolites ◽  
Gastrocnemius Muscles

Static contraction of hind-limb muscles is well known to increase reflexly cardiovascular function. Recently, blockade of cyclooxygenase activity has been reported to attenuate the reflex pressor response to contraction, a finding which suggests that working skeletal muscle releases arachidonic acid metabolites. Therefore, we measured the effects of static contraction and ischemia on arachidonic acid levels in the gastrocnemius muscles of barbiturate-anesthetized cats treated with indomethacin. Unesterified arachidonic acid levels were measured by high-pressure liquid chromatography. We found that static contraction of freely perfused gastrocnemius muscles increased arachidonic acid levels from 4.4 +/- 1.0 to 10.3 +/- 2.2 nmol/g wet wt (n = 12; P less than 0.005). Likewise, static contraction of gastrocnemius muscles made ischemic for 2 min before the onset of the contraction period increased arachidonic acid levels from 12.6 +/- 2.3 to 21.0 +/- 2.0 nmol/g wet wt (n = 12; P less than 0.01). Lastly, 2 min of ischemia with the gastrocnemius muscles at rest increased arachidonic acid levels from 5.9 +/- 1.1 to 10.5 +/- 3.0 nmol/g wet wt (n = 18; P less than 0.02). We conclude that both static contraction and ischemia increase arachidonic acid levels in working hindlimb muscle.

Effects of Postconditioning on Skeletal Muscle Injury and Apoptosis Induced by Partial Ischemia and Reperfusion in Rats

2017 ◽  
Vol 40 ◽  
pp. 285-293 ◽  
Author(s):  
José Alves Lintz ◽  
Marcelo Bellini Dalio ◽  
Luiz Fernando Tirapelli ◽  
Maurício Serra Ribeiro ◽  
Edwaldo Edner Joviliano ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Injury ◽  
Ischemia And Reperfusion ◽  
Skeletal Muscle Injury

scholarly journals Stem Cells for the Treatment of Skeletal Muscle Injury

2009 ◽  
Vol 28 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Andres J. Quintero ◽  
Vonda J. Wright ◽  
Freddie H. Fu ◽  
Johnny Huard
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Muscle Injury ◽  
Skeletal Muscle Injury
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