Structure - Activity Relationships for Selected Sulfur-Rich Antifungal Compounds

1999 ◽  
Vol 52 (3) ◽  
pp. 167 ◽  
Author(s):  
Felix Jakob Baerlocher ◽  
Richard Francis Langler ◽  
Mathias Ugelstad Frederiksen ◽  
Noni Mandissa Georges ◽  
Ross Davidson Witherell
Keyword(s):  
Aspergillus Niger ◽  
Aspergillus Flavus ◽  
Sulfur Compounds ◽  
Antifungal Compounds ◽  
Structure Activity Relationships ◽  
Structure Activity

A series of sulfur compounds has been prepared and tested against two kinds of fungi: Aspergillus niger and Aspergillus flavus. Results on various sulfone disulfides and ester disulfides have led to the formulation of a proposed mechanism for fungicidal behaviour that permits one to anticipate which structures will be antifungal.

scholarly journals Synthesis & Antifungal Screening of Novel Azetidin-2-ones

2015 ◽  
Vol 2 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Apoorva Gupta ◽  
Anand K. Halve
Keyword(s):  
Antifungal Activity ◽  
Aspergillus Niger ◽  
Aspergillus Flavus ◽  
Elemental Analysis ◽  
Spectroscopic Data ◽  
Activity Relationship ◽  
Synthetic Route ◽  
Chemical Structures ◽  
Structure Activity ◽  
Significant Structure

A new series of 4-[3-chloro-2-(4-hydroxy-3-methoxybenzyllidene)-4-oxoazetidin-1-yl]amino-N-(substituted)benzenesulfonamide, 4-{3-chloro-2-[5-methoxy-2-nitro-4-(prop-2-en-1-yloxy)benz yllidene]-4-oxoazetidin-1-yl}]amino}-N-(substituted)benzenesulfonamide and 4-{3-chloro-2-[4-hydroxy-3-methoxy-5-(prop-2-en-1-yl)benzylidene]-4-oxoazetidin-1-yl}amino}-N-(substituted) benzenesulfonamide were synthesized using appropriate synthetic route. The chemical structures of all the synthesized compounds were deduced on the basis of elemental analysis and spectroscopic data. The antifungal activity of the synthesized compounds was screened against several fungus. The synthesized compounds show potent antifungal activity against Aspergillus niger & Aspergillus flavus and significant structure-activity relationship (SAR) trends.

Structure-activity relationships in the acronycine and benzo[b]acronycine series: Role of the pyran ring

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
Q Do ◽  
H Doan Thi Mai ◽  
T Gaslonde ◽  
B Pfeiffer ◽  
S Léonce ◽  
...  
Keyword(s):  
Pyran Ring ◽  
Structure Activity Relationships ◽  
Structure Activity

Structure activity-relationships of P-Glycoprotein modulation using a small library of macrocyclic lathyrane diterpenes

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
M Reis ◽  
RJ Ferreira ◽  
MMM Santos ◽  
DJVA dos Santos ◽  
J Molnár ◽  
...  
Keyword(s):  
Structure Activity Relationships ◽  
Structure Activity ◽  
P Glycoprotein
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