The Synthesis and Biological Evaluation of Some C-9 and C-10 Substituted Derivatives of the RNA Polymerase I Transcription Inhibitor CX-5461

2021 ◽  
Author(s):  
Madushani Amarasiri ◽  
Yen Vo ◽  
Michael G. Gardiner ◽  
Perlita Poh ◽  
Priscilla Soo ◽  
...  
Keyword(s):  
Rna Polymerase ◽  
Biological Evaluation ◽  
Rna Polymerase I ◽  
Transcription Inhibitor ◽  
Polymerase I ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of

scholarly journals First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study

2019 ◽  
Vol 9 (8) ◽  
pp. 1036-1049 ◽  
Author(s):  
Amit Khot ◽  
Natalie Brajanovski ◽  
Donald P. Cameron ◽  
Nadine Hein ◽  
Kylee H. Maclachlan ◽  
...  
Keyword(s):  
Rna Polymerase ◽  
Phase I ◽  
Dose Escalation ◽  
Rna Polymerase I ◽  
Dose Escalation Study ◽  
Transcription Inhibitor ◽  
Polymerase I

scholarly journals rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461

2020 ◽  
Vol 8 ◽  
Author(s):  
Jinbae Son ◽  
Katherine M. Hannan ◽  
Gretchen Poortinga ◽  
Nadine Hein ◽  
Donald P. Cameron ◽  
...  
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase I ◽  
Transcription Inhibitor ◽  
Polymerase I
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