scholarly journals Radiolabelled Peptides: Optimal Candidates for Theranostic Application in Oncology

2021 ◽  
Author(s):  
Andrew J. Hall ◽  
Mohammad B. Haskali
Keyword(s):  
Radiolabelled Peptides

Radiolabelled Peptides: Eon in Radiopharmaceutical

2009 ◽  
Vol 2 (3) ◽  
pp. 199-213
Author(s):  
Vikash Kumar ◽  
Permender Rathee ◽  
Kanchan Kohli ◽  
Hema Chaudhary ◽  
Sushila Rathee
Keyword(s):  
Radiolabelled Peptides

scholarly journals Albumin-derived peptides efficiently reduce renal uptake of radiolabelled peptides

2009 ◽  
Vol 37 (2) ◽  
pp. 226-234 ◽  
Author(s):  
Erik Vegt ◽  
Annemarie Eek ◽  
Wim J. G. Oyen ◽  
Marion de Jong ◽  
Martin Gotthardt ◽  
...  
Keyword(s):  
Renal Uptake ◽  
Radiolabelled Peptides

Radiolabelled peptides - promises and pitfalls

2000 ◽  
Vol 21 (6) ◽  
pp. 507-509 ◽  
Author(s):  
S. J. MATHER
Keyword(s):  
Radiolabelled Peptides

Radiopharmaceutical development of radiolabelled peptides

2012 ◽  
Vol 39 (S1) ◽  
pp. 11-30 ◽  
Author(s):  
Melpomeni Fani ◽  
Helmut R. Maecke
Keyword(s):  
Radiolabelled Peptides

Biokinetics and dosimetry of several radiolabelled peptides in cancer cells

2007 ◽  
Vol 162 (10-11) ◽  
pp. 797-801
Author(s):  
J. Rodríguez-Cortés ◽  
G. Ferro-Flores ◽  
C. Arteaga De Murphy ◽  
M. Pedraza-López ◽  
MA. T. Ramírez-Iglesias
Keyword(s):  
Cancer Cells ◽  
Radiolabelled Peptides

scholarly journals Radiolabelled peptides for oncological diagnosis

2012 ◽  
Vol 39 (S1) ◽  
pp. 78-92 ◽  
Author(s):  
Peter Laverman ◽  
Jane K. Sosabowski ◽  
Otto C. Boerman ◽  
Wim J. G. Oyen
Keyword(s):  
Radiolabelled Peptides

scholarly journals Therapeutic use of radiolabelled peptides

2000 ◽  
Vol 11 ◽  
pp. 267-272 ◽  
Author(s):  
Eric P. Krenning ◽  
Marion de Jong
Keyword(s):  
Therapeutic Use ◽  
Radiolabelled Peptides

scholarly journals [18F]FET-βAG-TOCA: The Design, Evaluation and Clinical Translation of a Fluorinated Octreotide

Cancers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 865 ◽  
Author(s):  
Louis Allott ◽  
Suraiya Dubash ◽  
Eric O. Aboagye
Keyword(s):  
Somatostatin Receptor ◽  
Peptide Receptor Radionuclide Therapy ◽  
Somatostatin Analogues ◽  
Good Manufacturing Practice ◽  
Biological Evaluation ◽  
Clinical Translation ◽  
Prosthetic Group ◽  
Radiolabelled Peptides ◽  
Gallium 68

The success of Lutathera™ ([177Lu]Lu-DOTA-TATE) in the NETTER-1 clinical trial as a peptide receptor radionuclide therapy (PRRT) for somatostatin receptor expressing (SSTR) neuroendocrine tumours (NET) is likely to increase the demand for patient stratification by positron emission tomography (PET). The current gold standard of gallium-68 radiolabelled somatostatin analogues (e.g., [68Ga]Ga-DOTA-TATE) works effectively, but access is constrained by the limited availability and scalability of gallium-68 radiopharmaceutical production. The aim of this review is three-fold: firstly, we discuss the peptide library design, biological evaluation and clinical translation of [18F]fluoroethyltriazole-βAG-TOCA ([18F]FET-βAG-TOCA), our fluorine-18 radiolabelled octreotide; secondly, to exemplify the potential of the 2-[18F]fluoroethylazide prosthetic group and copper-catalysed azide-alkyne cycloaddition (CuAAC) chemistry in accessing good manufacturing practice (GMP) compatible radiopharmaceuticals; thirdly, we aim to illustrate a framework for the translation of similarly radiolabelled peptides, in which in vivo pharmacokinetics drives candidate selection, supported by robust radiochemistry methodology and a route to GMP production. It is hoped that this review will continue to inspire the development and translation of fluorine-18 radiolabelled peptides into clinical studies for the benefit of patients.

Use of the rat pancreatic CA20948 cell line for the comparison of radiolabelled peptides for receptor-targeted scintigraphy and radionuclide therapy

2000 ◽  
Vol 21 (11) ◽  
pp. 1079-1085 ◽  
Author(s):  
B. F. BERNARD ◽  
E. KRENNING ◽  
W. A.P. BREEMAN ◽  
T. J. VISSER ◽  
W. H. BAKKER ◽  
...  
Keyword(s):  
Cell Line ◽  
Radionuclide Therapy ◽  
Radiolabelled Peptides
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