scholarly journals Rapid glucocorticoid inhibition of vasoactive intestinal peptide-induced cyclic AMP accumulation and prolactin release in rat pituitary cells in culture.

1981 ◽  
Vol 78 (12) ◽  
pp. 7584-7588 ◽  
Author(s):  
W. H. Rotsztejn ◽  
M. Dussaillant ◽  
F. Nobou ◽  
G. Rosselin
Keyword(s):  
Cyclic Amp ◽  
Vasoactive Intestinal Peptide ◽  
Pituitary Cells ◽  
Prolactin Release ◽  
Cells In Culture ◽  
Cyclic Amp Accumulation ◽  
Rat Pituitary ◽  
Rat Pituitary Cells

A COMPARISON OF THE EFFECTS OF FOUR ERGOT DERIVATIVES ON PROLACTIN SECRETION BY DISPERSED RAT PITUITARY CELLS

1980 ◽  
Vol 87 (1) ◽  
pp. 95-103 ◽  
Author(s):  
G. DELITALA ◽  
T. YEO ◽  
ASHLEY GROSSMAN ◽  
N. R. HATHWAY ◽  
G. M. BESSER
Keyword(s):  
Anterior Pituitary ◽  
Ergot Alkaloids ◽  
Prolactin Secretion ◽  
Pituitary Cells ◽  
Inhibitory Effects ◽  
Prolactin Release ◽  
Ergot Derivatives ◽  
Rat Pituitary ◽  
Rat Pituitary Cells

The inhibitory effects of dopamine and various ergot alkaloids on prolactin secretion were studied using continuously perfused columns of dispersed rat anterior pituitary cells. Bromocriptine (5 nmol/l) and lisuride hydrogen maleate (5 nmol/l) both inhibited prolactin secretion, the effects persisting for more than 3 h after the end of the administration of the drugs. A similar although less long-lasting effect was observed with lergotrile (50 nmol/l) and the new ergoline derivative, pergolide (5 nmol/l). These effects contrasted with the rapid disappearance of the action of dopamine. The potency estimates of the ergots relative to that of dopamine were: lergotrile, 2·3; bromocriptine, 13; lisuride, 15; pergolide, 23. The dopamine-receptor blocking drugs, metoclopramide and haloperidol, antagonized the prolactin release-inhibiting activity of the compounds; bromocriptine and lisuride showed the highest resistance to this dopaminergic blockade. The results suggested that the direct effect of the ergot derivatives on dispersed pituitary cells was mediated through dopamine receptors and emphasized the long-lasting action of bromocriptine and lisuride in vitro.

Control of the production of two protein hormones by rat pituitary cells in culture

In Vitro ◽  
1970 ◽  
Vol 6 (3) ◽  
pp. 180-189 ◽  
Author(s):  
Frank C. Bancroft ◽  
Armen H. Tashjian
Keyword(s):  
Pituitary Cells ◽  
Cells In Culture ◽  
Rat Pituitary ◽  
Rat Pituitary Cells
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