scholarly journals Isolation and characterization of iron-independent positive dominant mutants of the diphtheria toxin repressor DtxR

1998 ◽  
Vol 95 (25) ◽  
pp. 14985-14990 ◽  
Author(s):  
L. Sun ◽  
J. vanderSpek ◽  
J. R. Murphy
Keyword(s):  
Diphtheria Toxin ◽  
Isolation And Characterization ◽  
Diphtheria Toxin Repressor ◽  
Dominant Mutants

scholarly journals MITOTIC RECOMBINATION IN YEAST: ISOLATION AND CHARACTERIZATION OF MUTANTS WITH ENHANCED SPONTANEOUS MITOTIC GENE CONVERSION RATES

Genetics ◽  
1980 ◽  
Vol 94 (4) ◽  
pp. 825-839
Author(s):  
Daniel H Maloney ◽  
Seymour Fogel
Keyword(s):  
Mitotic Recombination ◽  
Haploid Strain ◽  
Isolation And Characterization ◽  
Conversion Rates ◽  
Enzyme Defects ◽  
Mitotic Gene Conversion ◽  
Yeast Isolation ◽  
Forward Mutation ◽  
Dominant Mutants

ABSTRACT Semi-dominant mutants displaying greatly elevated (up to 200-fold above control) levels of spontaneous mitotic recombination have been isolated in a disomic haploid strain of yeast heteroallelic at the arg4 locus. They are designated by the symbol MIC. The mutants variously exhibit associated sensitivity to UV and ionizing radiation and to methyl methanesulfonate, enhanced UV-induced mitotic recombination, and enhanced spontaneous forward mutation rates. Possible enzyme defects and involvement in repair and editing of DNA are discussed. The mutants are expected to simplify the analysis of recombination pathways in yeast.

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