scholarly journals Attenuated Zymosan-induced Peritoneal Vascular Permeability and IgE-dependent Passive Cutaneous Anaphylaxis in Mice Lacking Leukotriene C4Synthase

2001 ◽  
Vol 276 (25) ◽  
pp. 22608-22613 ◽  
Author(s):  
Yoshihide Kanaoka ◽  
Akiko Maekawa ◽  
John F. Penrose ◽  
K. Frank Austen ◽  
Bing K. Lam
Keyword(s):  
Vascular Permeability ◽  
Passive Cutaneous Anaphylaxis

scholarly journals IMMUNOLOGICAL INDUCTION OF INCREASED VASCULAR PERMEABILITY

1969 ◽  
Vol 129 (1) ◽  
pp. 153-165 ◽  
Author(s):  
P. M. Henson ◽  
C. G. Cochrane
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Vascular Permeability ◽  
Bovine Serum ◽  
Cobra Venom ◽  
Passive Cutaneous Anaphylaxis ◽  
Cobra Venom Factor ◽  
Heat Stable

Passive cutaneous anaphylaxis (PCA) reactions were produced in rabbits by antibodies to bovine serum albumin. Two types of antibodies were found, each inducing increased vascular permeability, but by means of different mediation systems. One of these antibodies required the presence of complement, platelets, and neutrophils for the induction of the PCA reaction, which was inhibited by antihistamine. This antibody was heat stable, sedimented in the 7S region, and was found in both fast and slow electrophoretic fractions of rabbit γ-globulin. Homocytotropic antibody was also detected. The PCA reactions induced by this type of antibody did not require platelets or neutrophils and were not inhibited in rabbits depleted of C3 with cobra venom factor. The lesions were, however, prevented by administration of antihistamine.

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