An Accessory Agonist Binding Site Promotes Activation of α4β2* Nicotinic Acetylcholine Receptors

Acetylcholine Receptors ◽

Agonist Binding ◽

Insights into a highly conserved network of hydrogen bonds in the agonist binding site of nicotinic acetylcholine receptors: A structural and theoretical study

Proteins Structure Function and Bioinformatics ◽

10.1002/prot.24589 ◽

2014 ◽

Vol 82 (10) ◽

pp. 2303-2317

Author(s):

Alexandre Atkinson ◽

Jérôme Graton ◽

Jean-Yves Le Questel

Keyword(s):

Hydrogen Bonds ◽

Binding Site ◽

Acetylcholine Receptors ◽

Theoretical Study ◽

Agonist Binding ◽

Nicotinic Acetylcholine ◽

Network Of Hydrogen Bonds

Thinking Outside the Box: Residues that Shape the Agonist Binding Site of Nicotinic Acetylcholine Receptors

Biophysical Journal ◽

10.1016/j.bpj.2009.12.715 ◽

2010 ◽

Vol 98 (3) ◽

pp. 132a

Author(s):

Nyssa L. Puskar ◽

Xinan Xiu ◽

Henry A. Lester ◽

Dennis A. Dougherty

Keyword(s):

Binding Site ◽

Acetylcholine Receptors ◽

Agonist Binding ◽

Nicotinic Acetylcholine ◽

Outside The Box

The Unique α4(+)/(−)α4 Agonist Binding Site in (α4)3(β2)2 Subtype Nicotinic Acetylcholine Receptors Permits Differential Agonist Desensitization Pharmacology versus the (α4)2(β2)3 Subtype

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.113.208389 ◽

2013 ◽

Vol 348 (1) ◽

pp. 46-58 ◽

Cited By ~ 34

Author(s):

J. Brek Eaton ◽

Linda M. Lucero ◽

Harrison Stratton ◽

Yongchang Chang ◽

John F. Cooper ◽

...

Keyword(s):

Binding Site ◽

Acetylcholine Receptors ◽

Agonist Binding ◽

Stable desensitization of α7 nicotinic acetylcholine receptors by NS6740 requires interaction with S36 in the orthosteric agonist binding site

European Journal of Pharmacology ◽

10.1016/j.ejphar.2021.174179 ◽

2021 ◽

pp. 174179

Author(s):

Maria Chiara Pismataro ◽

Nicole A. Horenstein ◽

Clare Stokes ◽

Clelia Dallanoce ◽

Ganesh A. Thakur ◽

...

Keyword(s):

Binding Site ◽

Α7 Nicotinic Acetylcholine Receptors

Acetylcholine Receptors ◽

Agonist Binding ◽

Nicotinic Acetylcholine ◽

Amino acids outside of the loops that define the agonist binding site are important for ligand binding to insect nicotinic acetylcholine receptors

Journal of Neurochemistry ◽

10.1111/j.1471-4159.2008.05359.x ◽

2008 ◽

Vol 106 (1) ◽

pp. 224-230 ◽

Cited By ~ 14

Author(s):

Zewen Liu ◽

Zhaojun Han ◽

Shuhua Liu ◽

Yixi Zhang ◽

Feng Song ◽

...

Keyword(s):

Amino Acids ◽

Ligand Binding ◽

Binding Site ◽

Acetylcholine Receptors ◽

Agonist Binding ◽

[3H]Epibatidine Photolabels Non-equivalent Amino Acids in the Agonist Binding Site ofTorpedoand α4β2 Nicotinic Acetylcholine Receptors

Journal of Biological Chemistry ◽

10.1074/jbc.m109.019083 ◽

2009 ◽

Vol 284 (37) ◽

pp. 24939-24947 ◽

Cited By ~ 11

Author(s):

Shouryadeep Srivastava ◽

Ayman K. Hamouda ◽

Akash Pandhare ◽

Phaneendra K. Duddempudi ◽

Mitesh Sanghvi ◽

...

Keyword(s):

Amino Acids ◽

Binding Site ◽

Acetylcholine Receptors ◽

Agonist Binding ◽

A Novel Agonist Binding Site on Nicotinic Acetylcholine Receptors

Journal of Receptor Research ◽

10.3109/10799899309073670 ◽

1993 ◽

Vol 13 (1-4) ◽

pp. 413-436 ◽

Cited By ~ 35

Author(s):

E. F. R. Pereira ◽

M. Alkondon ◽

T. Tano ◽

N. G. Castro ◽

M. M. Fróes-Ferra¯o ◽

...

Keyword(s):

Binding Site ◽

Acetylcholine Receptors ◽

Agonist Binding ◽

The α–α interface: A hidden binding site of neonicotinoids at nicotinic acetylcholine receptors

10.1603/ice.2016.91223 ◽

2016 ◽

Author(s):

Kazuhiko Matsuda

Keyword(s):

Binding Site ◽

Acetylcholine Receptors ◽

Molecular mechanisms and binding site locations for noncompetitive antagonists of nicotinic acetylcholine receptors

The International Journal of Biochemistry & Cell Biology ◽

10.1016/j.biocel.2006.01.006 ◽

2006 ◽

Vol 38 (8) ◽

pp. 1254-1276 ◽

Cited By ~ 88

Author(s):

Hugo R. Arias ◽

Pankaj Bhumireddy ◽

Cecilia Bouzat

Keyword(s):

Binding Site ◽

Acetylcholine Receptors ◽

Molecular Mechanisms ◽

Identifying the Binding Site of Novel Methyllycaconitine (MLA) Analogs at α4β2 Nicotinic Acetylcholine Receptors

ACS Chemical Neuroscience ◽

10.1021/cn100073x ◽

2010 ◽

Vol 1 (12) ◽

pp. 796-809 ◽

Cited By ~ 8

Author(s):

Gracia X. J. Quek ◽

Diana Lin ◽

Jill I. Halliday ◽

Nathan Absalom ◽

Joseph I. Ambrus ◽

...

Keyword(s):

Binding Site ◽

Acetylcholine Receptors ◽