scholarly journals Functional Human Mitochondrial DNA Polymerase γ Forms a Heterotrimer

2005 ◽  
Vol 281 (1) ◽  
pp. 374-382 ◽  
Author(s):  
Elena Yakubovskaya ◽  
Zhixin Chen ◽  
José A. Carrodeguas ◽  
Caroline Kisker ◽  
Daniel F. Bogenhagen
Keyword(s):  
Mitochondrial Dna ◽  
Dna Polymerase ◽  
Human Mitochondrial Dna ◽  
Mitochondrial Dna Polymerase ◽  
Dna Polymerase Γ

scholarly journals Mechanism of Interaction of Human Mitochondrial DNA Polymerase γ with the Novel Nucleoside Reverse Transcriptase Inhibitor 4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine Indicates a Low Potential for Host Toxicity

2011 ◽  
Vol 56 (3) ◽  
pp. 1630-1634 ◽  
Author(s):  
Christal D. Sohl ◽  
Kamlendra Singh ◽  
Rajesh Kasiviswanathan ◽  
William C. Copeland ◽  
Hiroaki Mitsuya ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Dna Polymerase ◽  
Transcriptase Inhibitor ◽  
Clinical Settings ◽  
Human Mitochondrial Dna ◽  
Steady State Kinetics ◽  
Mechanism Of Interaction ◽  
Reverse Transcriptase Inhibitor ◽  
Mitochondrial Dna Polymerase ◽  
Dna Polymerase Γ

ABSTRACTThe potent antiretroviral 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) is a promising experimental agent for treating HIV infection. Pre-steady-state kinetics were used to characterize the interaction of EFdA-triphosphate (EFdA-TP) with human mitochondrial DNA polymerase γ (Pol γ) to assess the potential for toxicity. Pol γ incorporated EFdA-TP 4,300-fold less efficiently than dATP, with an excision rate similar to ddATP. This strongly indicates EFdA is a poor Pol γ substrate, suggesting minimal Pol γ-mediated toxicity, although this should be examined under clinical settings.

Human Mitochondrial DNA Polymerase Holoenzyme: Reconstitution and Characterization†

Biochemistry ◽  
2000 ◽  
Vol 39 (7) ◽  
pp. 1702-1708 ◽  
Author(s):  
Allison A. Johnson ◽  
Yu-chih Tsai ◽  
Steven W. Graves ◽  
Kenneth A. Johnson
Keyword(s):  
Mitochondrial Dna ◽  
Dna Polymerase ◽  
Human Mitochondrial Dna ◽  
Mitochondrial Dna Polymerase

scholarly journals Mitochondrial DNA polymerase-γ and human disease

2006 ◽  
Vol 15 (suppl_2) ◽  
pp. R244-R252 ◽  
Author(s):  
Gavin Hudson ◽  
Patrick F. Chinnery
Keyword(s):  
Mitochondrial Dna ◽  
Dna Polymerase ◽  
Human Disease ◽  
Mitochondrial Dna Polymerase ◽  
Dna Polymerase Γ
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