Contact Allergy in the Burning Mouth Syndrome: a Retrospective Study on 38 Patients

Abstract Background Burning mouth syndrome (BMS) is a chronic condition characterized by pain in the oral cavity. Kampo medicine is a traditional Japanese medical system, which has its roots partly in ancient Chinese medicine. The purpose of this study is to evaluate the efficacy of rikkosan—a traditional Japanese herbal medicine (kampo)—in the treatment of primary BMS. Main body: A single-center retrospective study was conducted in 32 patients who were diagnosed with primary BMS and treated with rikkosan alone through gargling (2.5 g rikkosan dissolved in 50 mL hot water) three times daily. Patients were asked to evaluate their pain using the numerical rating scale (NRS) at first visit, after 1 month, and the end of rikkosan treatment. One patient had stomatitis as a side effect after gargling with rikkosan, however, no side effects were observed in other patients. Overall NRS scores decreased significantly between the first visit (7.6 ± 2.7) and the end of treatment with rikkosan (4.4 ± 3.3). Conclusions Rikkosan may be an effective treatment for primary BMS.

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Contact allergy to denture materials in the burning mouth syndrome

Contact Dermatitis ◽

10.1111/j.1600-0536.1988.tb02748.x ◽

1988 ◽

Vol 18 (2) ◽

pp. 97-99 ◽

Cited By ~ 56

Author(s):

Th. van Joost ◽

J. van Ulsen ◽

L. A. J. van Loon

Keyword(s):

Contact Allergy ◽

Burning Mouth Syndrome ◽

Burning Mouth

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Burning mouth syndrome and associated factors: A case–control retrospective study

Medicina Clínica (English Edition) ◽

10.1016/j.medcle.2017.02.012 ◽

2017 ◽

Vol 148 (4) ◽

pp. 153-157

Author(s):

Eduardo Chimenos-Küstner ◽

Fiorella de Luca-Monasterios ◽

Mayra Schemel-Suárez ◽

María E. Rodríguez de Rivera-Campillo ◽

Alejandro M. Pérez-Pérez ◽

...

Keyword(s):

Retrospective Study ◽

Associated Factors ◽

Case Control ◽

Burning Mouth Syndrome ◽

Burning Mouth

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Burning Mouth Syndrome

Journal of Cutaneous Medicine and Surgery ◽

10.2310/7750.2013.13096 ◽

2014 ◽

Vol 18 (3) ◽

pp. 174-179 ◽

Cited By ~ 11

Author(s):

Carrie B. Lynde ◽

Miriam Grushka ◽

Scott R.A. Walsh

Keyword(s):

Patch Testing ◽

Clinical Utility ◽

Contact Allergy ◽

Nickel Sulfate ◽

Burning Mouth Syndrome ◽

Etiologic Factor ◽

Dodecyl Gallate ◽

Test Reactions ◽

Burning Mouth ◽

Positive Results

Background: Burning mouth syndrome (BMS) is a burning or sore mouth in the absence of changes in the oral mucosa. It is often difficult to diagnose and treat. Numerous theories of the etiology have been suggested, including contact allergy. Objective: To determine the clinical utility of patch testing in patients with BMS. Methods: We retrospectively reviewed the charts of patients diagnosed with BMS who had patch testing performed between January 1, 2008, and July 31, 2012. Results: Of 142 consecutive patients with BMS, 132 consented to patch testing; 89 (67%) had allergic patch test reactions. Of the patients with positive results, 66 (74%) had results that were deemed to have possible relevance. The most common allergens detected were nickel sulfate 2.5%, dodecyl gallate 0.3%, octyl gallate 0.3%, fragrance mix 8%, benzoyl peroxide 1%, and cinnamic alcohol 1%. Conclusions: Our findings suggest that contact allergy may be an etiologic factor in some patients with BMS. Patch testing is a useful investigation for BMS patients.

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