Analysis and mathematical computation of some dynamic functions for the guanidine zinc sulfate

Zinc sulfate is the main component in the composition of the acidic zinc plating electrolyte. Deviation in the electrolyte composition from the optimum content leads to destabilization of the electrolysis process and deteriorate the quality of the resulting zinc coating. The proper quality of a zinc coating obtained by galvanic deposition can be ensured only with timely monitoring and adjustment of the electrolyte composition. A technique of X-ray fluorescence determination of zinc (in terms of zinc sulfate) in an acidic zinc plating electrolyte is proposed. The study was carried out using an ARL Quant’X energy dispersive spectrometer (Thermo Fisher Scientific, USA) with a semiconductor silicon-lithium detector. The features of the spectrometer design are presented. The optimal parameters of excitation and detection of zinc radiation were specified when the electrolyte sample was diluted 1:1000. The ZnKα1 line was used as an analytical line. The plotted calibration graph is linear, the correlation coefficient being 0.999234. The results of zinc determination according to the developed method were compared with the data of the reference method of complexometric titration to prove the reliability of the procedure. The results are characterized by good convergence and accuracy. The proposed method of X-ray fluorescence zinc determination in a zinc plating electrolyte equals complexometric titration in the limiting capabilities and even exceeds the latter in terms of the simplicity of sample preparation and rapidity. The developed method of X-ray fluorescence determination of zinc is implemented in analysis of the electrolyte used in the continuous galvanizing unit at «METSERVIS LLC».

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Faculty Opinions recommendation of Randomized, double-blind trial of 220 mg zinc sulfate twice daily in the treatment of rosacea.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717955450.793460501 ◽

2012 ◽

Author(s):

Dietrich Abeck

Keyword(s):

Zinc Sulfate ◽

Double Blind Trial ◽

Double Blind ◽

Blind Trial

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Zinc Sulfate Stimulates Osteogenic Phenotypes in Periosteum-Derived Cells and Co-Cultures of Periosteum-Derived Cells and THP-1 Cells

Life ◽

10.3390/life11050410 ◽

2021 ◽

Vol 11 (5) ◽

pp. 410

Author(s):

Jin-Ho Park ◽

Su A Park ◽

Young-Hoon Kang ◽

So Myeong Hwa ◽

Eun-Byeol Koh ◽

...

Keyword(s):

Bone Resorption ◽

Zinc Sulfate ◽

Nuclear Factor Kappa B ◽

Osteoblastic Differentiation ◽

Nuclear Factor ◽

Mitogen Activated Protein Kinases ◽

Extracellular Signaling ◽

Receptor Activator ◽

Mitogen Activated Protein ◽

Osteoclastic Differentiation

Coupling between osteoblast-mediated bone formation and osteoclast-mediated bone resorption maintains both mechanical integrity and mineral homeostasis. Zinc is required for the formation, mineralization, growth, and maintenance of bones. We examined the effects of zinc sulfate on osteoblastic differentiation of human periosteum-derived cells (hPDCs) and osteoclastic differentiation of THP-1 cells. Zinc sulfate enhanced the osteoblastic differentiation of hPDCs; however, it did not affect the osteoclastic differentiation of THP-1 cells. The levels of extracellular signaling-related kinase (ERK) were strongly increased during osteoblastic differentiation in zinc sulfate-treated hPDCs, compared with other mitogen-activated protein kinases (MAPKs). Zinc sulfate also promoted osteogenesis in hPDCs and THP-1 cells co-cultured with the ratio of one osteoclast to one osteoblast, as indicated by alkaline phosphatase levels, mineralization, and cellular calcium contents. In addition, the receptor activator of nuclear factor kappa B ligand (RANKL)/osteoprotegerin (OPG) ratio was decreased in the zinc sulfate-treated co-cultures. Our results suggest that zinc sulfate enhances osteogenesis directly by promoting osteoblastic differentiation and osteogenic activities in osteoblasts and indirectly by inhibiting osteoclastic bone resorption through a reduced RANKL/OPG ratio in co-cultured osteoblasts and osteoclasts.

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