Metabolism, pharmacokinetics and excretion of a potent tachykinin NK1 receptor antagonist (CP-122,721) in rat: Characterization of a novel oxidative pathway

Xenobiotica ◽  
2006 ◽  
Vol 36 (2-3) ◽  
pp. 235-258 ◽  
Author(s):  
A. Kamel ◽  
J. Davis ◽  
M. J. Potchoiba ◽  
C. Prakash
Keyword(s):  
Receptor Antagonist ◽  
Nk1 Receptor ◽  
Nk1 Receptor Antagonist ◽  
Oxidative Pathway

Characterization of the binding and activity of a high affinity, pseudoirreversible morpholino tachykinin NK1 receptor antagonist

1997 ◽  
Vol 325 (2-3) ◽  
pp. 253-261 ◽  
Author(s):  
Margaret A Cascieri ◽  
Elzbieta Ber ◽  
Tung Ming Fong ◽  
Jeffrey J Hale ◽  
Frank Tang ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Nk1 Receptor ◽  
High Affinity ◽  
Nk1 Receptor Antagonist

Pharmacological characterization of GR82334, a tachykinin NK1 receptor antagonist, in the isolated spinal cord of the neonatal rat

1995 ◽  
Vol 281 (1) ◽  
pp. 49-54 ◽  
Author(s):  
Jian-Zhong Guo ◽  
Koichi Yoshioka ◽  
Fei-Yue Zhao ◽  
Rumiko Hosoki ◽  
Taketoshi Maehara ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Receptor Antagonist ◽  
Neonatal Rat ◽  
Nk1 Receptor ◽  
Pharmacological Characterization ◽  
Nk1 Receptor Antagonist

Anxiolytic effect of NKP608, a NK1-receptor antagonist, in the social investigation test in gerbils

2002 ◽  
Vol 133 (2) ◽  
pp. 363-368 ◽  
Author(s):  
Conrad Gentsch ◽  
Margaret Cutler ◽  
Annick Vassout ◽  
Siem Veenstra ◽  
Felix Brugger
Keyword(s):  
Receptor Antagonist ◽  
Anxiolytic Effect ◽  
Nk1 Receptor ◽  
Social Investigation ◽  
The Social ◽  
Nk1 Receptor Antagonist

Anti-emetic profile of a non-peptide neurokinin NK1 receptor antagonist, CP-99,994, in ferrets

1993 ◽  
Vol 249 (1-2) ◽  
pp. R3-R4 ◽  
Author(s):  
Chaz Bountra ◽  
Keith Bunce ◽  
Timothy Dale ◽  
Christopher Gardner ◽  
Christopher Jordan ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Nk1 Receptor ◽  
Nk1 Receptor Antagonist

scholarly journals Tachykinin NK1 receptor antagonist co-administration attenuates opioid withdrawal-mediated spinal microglia and astrocyte activation

2012 ◽  
Vol 684 (1-3) ◽  
pp. 64-70 ◽  
Author(s):  
Suneeta Tumati ◽  
Tally M. Largent-Milnes ◽  
Attila I. Keresztes ◽  
Takashi Yamamoto ◽  
Todd W. Vanderah ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Opioid Withdrawal ◽  
Nk1 Receptor ◽  
Astrocyte Activation ◽  
Nk1 Receptor Antagonist
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