HANDS 2019 - A decade of neutron scattering education in structural biology at Oak Ridge National Laboratory

Neutron News ◽  
2020 ◽  
Vol 31 (2-4) ◽  
pp. 9-10
Author(s):  
Flora Meilleur,
Keyword(s):  
Neutron Scattering ◽  
Structural Biology ◽  
National Laboratory ◽  
Oak Ridge ◽  
Oak Ridge National Laboratory

scholarly journals The suite of small-angle neutron scattering instruments at Oak Ridge National Laboratory

2018 ◽  
Vol 51 (2) ◽  
pp. 242-248 ◽  
Author(s):  
William T. Heller ◽  
Matthew Cuneo ◽  
Lisa Debeer-Schmitt ◽  
Changwoo Do ◽  
Lilin He ◽  
...  
Keyword(s):  
Neutron Scattering ◽  
Small Angle ◽  
Small Angle Neutron Scattering ◽  
Large Scale ◽  
National Laboratory ◽  
High Flux ◽  
Oak Ridge ◽  
Large Scale Structures ◽  
Oak Ridge National Laboratory ◽  
Scale Structures

Oak Ridge National Laboratory is home to the High Flux Isotope Reactor (HFIR), a high-flux research reactor, and the Spallation Neutron Source (SNS), the world's most intense source of pulsed neutron beams. The unique co-localization of these two sources provided an opportunity to develop a suite of complementary small-angle neutron scattering instruments for studies of large-scale structures: the GP-SANS and Bio-SANS instruments at the HFIR and the EQ-SANS and TOF-USANS instruments at the SNS. This article provides an overview of the capabilities of the suite of instruments, with specific emphasis on how they complement each other. A description of the plans for future developments including greater integration of the suite into a single point of entry for neutron scattering studies of large-scale structures is also provided.

scholarly journals Bio-SANS—A dedicated facility for neutron structural biology at Oak Ridge National Laboratory

2006 ◽  
Vol 385-386 ◽  
pp. 880-882 ◽  
Author(s):  
G.W. Lynn ◽  
William Heller ◽  
Volker Urban ◽  
G.D. Wignall ◽  
Kevin Weiss ◽  
...  
Keyword(s):  
Structural Biology ◽  
National Laboratory ◽  
Oak Ridge ◽  
Oak Ridge National Laboratory

The Bio-SANS Small-Angle Neutron Scattering Instrument at Oak Ridge National Laboratory

Neutron News ◽  
2008 ◽  
Vol 19 (2) ◽  
pp. 22-23 ◽  
Author(s):  
William T. Heller ◽  
Gary W. Lynn ◽  
Volker S. Urban ◽  
Kevin Weiss ◽  
Dean A.A. Myles
Keyword(s):  
Neutron Scattering ◽  
Small Angle ◽  
Small Angle Neutron Scattering ◽  
National Laboratory ◽  
Oak Ridge ◽  
Oak Ridge National Laboratory

The 40 m general purpose small-angle neutron scattering instrument at Oak Ridge National Laboratory

2012 ◽  
Vol 45 (5) ◽  
pp. 990-998 ◽  
Author(s):  
George D. Wignall ◽  
Kenneth C. Littrell ◽  
William T. Heller ◽  
Yuri B. Melnichenko ◽  
Kathy M. Bailey ◽  
...  
Keyword(s):  
Neutron Scattering ◽  
Small Angle ◽  
Small Angle Neutron Scattering ◽  
National Laboratory ◽  
Scattering Data ◽  
Large Area ◽  
High Count ◽  
Incident Wavelength ◽  
Oak Ridge ◽  
Oak Ridge National Laboratory

A series of upgrades have been undertaken at the High Flux Isotope Reactor (HFIR) at Oak Ridge National Laboratory, including the installation of a supercritical hydrogen moderator (T≃ 20 K), which has boosted the flux of long-wavelength neutrons by over two orders of magnitude. In order to take advantage of the new capabilities, a 40 m-long small-angle neutron scattering (SANS) instrument has been constructed, which utilizes a mechanical velocity selector, pinhole collimation and a high-count-rate (>105 Hz) large-area (1 m2) two-dimensional position-sensitive detector. The incident wavelength (λ), resolution (Δλ/λ), incident collimation and sample-to-detector distance are independently variable under computer control. The detector can be moved up to 45 cm off-axis to increase the overallQrange [<0.001 <Q= (4π/λ)sinθ < 1 Å−1, where 2θ is the angle of scatter]. The design and characteristics of this instrument are described, along with examples of scattering data to illustrate the performance.

The Bio-SANS instrument at the High Flux Isotope Reactor of Oak Ridge National Laboratory

2014 ◽  
Vol 47 (4) ◽  
pp. 1238-1246 ◽  
Author(s):  
William T. Heller ◽  
Volker S. Urban ◽  
Gary W. Lynn ◽  
Kevin L. Weiss ◽  
Hugh M. O'Neill ◽  
...  
Keyword(s):  
Neutron Scattering ◽  
National Laboratory ◽  
Isotopic Labeling ◽  
High Flux ◽  
Oak Ridge ◽  
Oak Ridge National Laboratory ◽  
User Facility ◽  
Technical Specifications ◽  
And Performance ◽  
Sans Instrument

Small-angle neutron scattering (SANS) is a powerful tool for characterizing complex disordered materials, including biological materials. The Bio-SANS instrument of the High Flux Isotope Reactor of Oak Ridge National Laboratory (ORNL) is a high-flux low-background SANS instrument that is, uniquely among SANS instruments, dedicated to serving the needs of the structural biology and biomaterials communities as an open-access user facility. Here, the technical specifications and performance of the Bio-SANS are presented. Sample environments developed to address the needs of the user program of the instrument are also presented. Further, the isotopic labeling and sample preparation capabilities available in the Bio-Deuteration Laboratory for users of the Bio-SANS and other neutron scattering instruments at ORNL are described. Finally, a brief survey of research performed using the Bio-SANS is presented, which demonstrates the breadth of the research that the instrument's user community engages in.

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