scholarly journals A method for reduction of human ventricular action potential model

2019 ◽  
Vol 26 (1) ◽  
pp. 1-30
Author(s):  
S. H. Sabzpoushan ◽  
A. Ghajarjazy
Keyword(s):  
Action Potential ◽  
Potential Model ◽  
Ventricular Action Potential

scholarly journals A Rabbit Ventricular Action Potential Model Replicating Cardiac Dynamics at Rapid Heart Rates

2008 ◽  
Vol 94 (2) ◽  
pp. 392-410 ◽  
Author(s):  
Aman Mahajan ◽  
Yohannes Shiferaw ◽  
Daisuke Sato ◽  
Ali Baher ◽  
Riccardo Olcese ◽  
...  
Keyword(s):  
Action Potential ◽  
Potential Model ◽  
Heart Rates ◽  
Cardiac Dynamics ◽  
Ventricular Action Potential

Reentry in heterogeneous cardiac tissue described by the Luo-Rudy ventricular action potential model

2003 ◽  
Vol 284 (2) ◽  
pp. H542-H548 ◽  
Author(s):  
K. H. W. J. Ten Tusscher ◽  
A. V. Panfilov
Keyword(s):  
Action Potential ◽  
Cardiac Tissue ◽  
Potential Model ◽  
Phase 1 ◽  
Spiral Wave ◽  
Spiral Waves ◽  
Local Current ◽  
Gradient Component ◽  
Reentrant Excitation ◽  
Ventricular Action Potential

Heterogeneity of cardiac tissue is an important factor determining the initiation and dynamics of cardiac arrhythmias. In this paper, we studied the effects of gradients of electrophysiological heterogeneity on reentrant excitation patterns using computer simulations. We investigated the dynamics of spiral waves in a two-dimensional sheet of cardiac tissue described by the Luo-Rudy phase 1 (LR1) ventricular action potential model. A gradient of action potential duration (APD) was imposed by gradually varying the local current density of K+ current or inward rectifying K+ current along one axis of the tissue sheet. We show that a gradient of APD resulted in spiral wave drift. This drift consisted of two components. The longitudinal (along the gradient) component was always directed toward regions of longer spiral wave period. The transverse (perpendicular to the gradient) component had a direction dependent on the direction of rotation of the spiral wave. We estimated the velocity of the drift as a function of the magnitude of the gradient and discuss its implications.

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