Side effects associated with pharmacotherapy for pediatric irritable bowel syndrome and functional abdominal pain – not otherwise specified: a systematic review

2019 ◽  
Vol 18 (2) ◽  
pp. 111-125 ◽  
Author(s):  
Robyn Rexwinkel ◽  
Judith Zeevenhooven ◽  
Faridi S. van Etten-Jamaludin ◽  
Marc A. Benninga ◽  
Merit M. Tabbers
Keyword(s):  
Systematic Review ◽  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Side Effects ◽  
Functional Abdominal Pain ◽  
Not Otherwise Specified ◽  
Irritable Bowel

scholarly journals Intestinal barrier dysfunction in irritable bowel syndrome: a systematic review

2021 ◽  
Vol 14 ◽  
pp. 175628482199358
Author(s):  
Nikita Hanning ◽  
Adam L. Edwinson ◽  
Hannah Ceuleers ◽  
Stephanie A. Peters ◽  
Joris G. De Man ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Barrier Function ◽  
Significant Proportion ◽  
Healthy Controls ◽  
Barrier Dysfunction ◽  
Irritable Bowel

Background and Aim: Irritable bowel syndrome (IBS) is a complex and heterogeneous disorder. Sensory, motor and barrier dysfunctions are the key physiological endophenotypes of IBS. Our aim is to review studies evaluating barrier dysfunction in adults and children with IBS, as well as to link those changes with IBS symptomatology and quality of life. Methods: A comprehensive and systematic review of multiple databases was performed up to March 2020 to identify studies comparing intestinal permeability in IBS patients with healthy controls. Both in vivo and in vitro studies were considered. Results: We identified 66 studies, of which 27 used intestinal probes to quantify barrier function. The prevalence of barrier dysfunction differed between PI-IBS (17–50%), IBS-D (37–62%) and IBS-C (4–25%). At a group level, permeability was increased compared with healthy controls in IBS-D (9/13 studies) and PI-IBS (4/4 studies), but only a minority of IBS-C (2/7 studies) and not in the only IBS-M study. All four studies in children with IBS demonstrated loss of barrier function. A heterogeneous set of tight junction genes were found to be altered in small and large intestines of adults with IBS, but these have not been evaluated in children. Positive associations were identified between barrier dysfunction and bowel disturbances (6/9 studies), abdominal pain (9/13 studies), overall symptom severity (1/6 studies), depression and anxiety (1/1 study) and quality of life (1/4 studies). Fecal slurry or supernatants of IBS patients were found to induce barrier disruption in animal models (5/6 studies). Conclusions: Barrier dysfunction is present in a significant proportion of adult and all pediatric IBS studies, especially in the IBS-D and PI-IBS subtype. The majority of studies indicated a positive association between loss of barrier function and symptoms such as abdominal pain and changes in the bowel function.

Stress reactivity in childhood functional abdominal pain or irritable bowel syndrome

2016 ◽  
Vol 21 (1) ◽  
pp. 166-177 ◽  
Author(s):  
M.D. Gulewitsch ◽  
K. Weimer ◽  
P. Enck ◽  
J. Schwille-Kiuntke ◽  
M. Hautzinger ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Stress Reactivity ◽  
Functional Abdominal Pain ◽  
Irritable Bowel

scholarly journals Capsule Endoscopy in Refractory Diarrhea-Predominant Irritable Bowel Syndrome and Functional Abdominal Pain

2018 ◽  
Vol 51 (6) ◽  
pp. 570-575 ◽  
Author(s):  
Manuel Valero ◽  
Gladys Bravo-Velez ◽  
Roberto Oleas ◽  
Miguel Puga-Tejada ◽  
Miguel Soria-Alcívar ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Capsule Endoscopy ◽  
Functional Abdominal Pain ◽  
Irritable Bowel

Annual Costs of Care for Pediatric Irritable Bowel Syndrome, Functional Abdominal Pain, and Functional Abdominal Pain Syndrome

2015 ◽  
Vol 167 (5) ◽  
pp. 1103-1108.e2 ◽  
Author(s):  
Daniël R. Hoekman ◽  
Juliette M.T.M. Rutten ◽  
Arine M. Vlieger ◽  
Marc A. Benninga ◽  
Marcel G.W. Dijkgraaf
Keyword(s):  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Pain Syndrome ◽  
Functional Abdominal Pain ◽  
Costs Of Care ◽  
Functional Abdominal Pain Syndrome ◽  
Irritable Bowel
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