scholarly journals Consequences of not-shaking and shake-fire delays on the emitted dose of some commercial solution and suspension pressurized metered dose inhalers

2020 ◽  
Vol 17 (7) ◽  
pp. 1025-1039
Author(s):  
Veronica Chierici ◽  
Luca Cavalieri ◽  
Alessio Piraino ◽  
Davide Paleari ◽  
Eride Quarta ◽  
...  
Keyword(s):  
Metered Dose Inhalers ◽  
Metered Dose ◽  
Emitted Dose ◽  
Pressurized Metered Dose Inhalers

scholarly journals Design of Pressurized Metered Dose Inhalers Modeling of Internal Flow and Atomization

2010 ◽  
Vol 4 (2) ◽  
Author(s):  
Henk Versteeg ◽  
Abdul Qaiyum Shaik
Keyword(s):  
Experimental Work ◽  
Equilibrium Model ◽  
Lung Diseases ◽  
Internal Flow ◽  
Flow Conditions ◽  
Metered Dose Inhalers ◽  
Numerical Predictions ◽  
Metered Dose ◽  
Flow Through ◽  
Pressurized Metered Dose Inhalers

Pressurized metered-dose inhalers (pMDIs) have been the most effective therapeutic treatment for controlling lung diseases such as asthma and COPD. The flow through a two-orifice system of pMDI is very complex and poorly understood. Previous experimental work has shown that metastability may play a significant role in determining the flow conditions inside pMDIs. In this paper, we present the findings of a homogeneous equilibrium model with those of a delayed equilibrium model (DEM) accounting for propellant metastability. These results are compared with the available experimental and numerical predictions Further, the DEM was applied with HFA propellants R134A and R227, and the results were compared with traditional propellant R12.

scholarly journals Imperative Instruction for Pressurized Metered-Dose Inhalers: Provider Perspectives

2018 ◽  
Vol 64 (3) ◽  
pp. 292-298
Author(s):  
Daniel C Schmitz ◽  
Rebecca A Ivancie ◽  
Kyung E Rhee ◽  
Heather C Pierce ◽  
Alicia O Cantu ◽  
...  
Keyword(s):  
Metered Dose Inhalers ◽  
Provider Perspectives ◽  
Metered Dose ◽  
Pressurized Metered Dose Inhalers

scholarly journals Formulation and evaluation of CFC free inhalers for beclomethasone dipropionate

2013 ◽  
Vol 49 (2) ◽  
pp. 221-231 ◽  
Author(s):  
Gopala Krishna Murthy Talasila ◽  
Bala Vishnu Priya Mukkala ◽  
Satyanarayana Vattikuri
Keyword(s):  
Quality Control ◽  
Fine Particle ◽  
Beclomethasone Dipropionate ◽  
Dry Powder Inhalers ◽  
Fine Particle Fraction ◽  
Particle Fraction ◽  
Metered Dose Inhalers ◽  
Spray Pattern ◽  
Metered Dose ◽  
Emitted Dose

Beclomethasone dipropionate CFC free inhalation formulations were developed with a view to treat asthma prophylactically. Dry powder inhalers (DPI) for beclomethasone dipropionate were prepared with different grades of lactose monohydrate. The influence of carrier and overages on performance of DPI was studied. Metered dose inhalers (MDI) with HFA based propellants were formulated with various doses, overages and different concentrations of alcohol. Formulated DPI and MDI were evaluated for various official and unofficial quality control tests. The influence of over doses on valve delivery, effect of overages on emitted dose and influence of alcohol on spray pattern from MDI were studied. The better fine particle fraction and emitted dose were obtained from the DPI formulated with 10:90 ratio of fine lactose: coarse lactose and with 20% w/w overages. The studies on MDI revealed that the 15% of overdoses are required for effective valve delivery and 20% overages are required for 100% drug delivery. 5-10%v/v alcohol was found to be preferable to get optimum emitted dose and fine particle fraction.

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