scholarly journals Short‐Course Therapy with Zidovudine Plus Lamivudine for Prevention of Mother‐to‐Child Transmission of Human Immunodeficiency Virus Type 1 in Thailand

2002 ◽  
Vol 35 (11) ◽  
pp. 1405-1413 ◽  
Author(s):  
Pongsakdi Chaisilwattana ◽  
Kulkanya Chokephaibulkit ◽  
Amphan Chalermchockcharoenkit ◽  
Nirun Vanprapar ◽  
Korakot Sirimai ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
Short Course ◽  
Immunodeficiency Virus ◽  
Mother To Child

scholarly journals Influence of human immunodeficiency virus type 1 subtype on mother-to-child transmission

2003 ◽  
Vol 84 (3) ◽  
pp. 607-613 ◽  
Author(s):  
Natàlia Tàpia ◽  
Sandra Franco ◽  
Francesc Puig-Basagoiti ◽  
Clara Menéndez ◽  
Pedro Luis Alonso ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Pregnant Women ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
Immunodeficiency Virus ◽  
Mother To Child ◽  
Hiv 1

The present study was designed to assess whether the subtype of human immunodeficiency virus type 1 (HIV-1) could affect the rate of HIV-1 mother-to-child transmission in a cohort of 31 HIV-1-seropositive pregnant Tanzanian women. In order to assign a subtype to the samples analysed, nucleotide sequencing of the HIV-1 long terminal repeat U3 and C2V3C3 envelope regions was performed from the sera of these 31 pregnant women. Except in three cases, amplification of both regions was achieved in all samples. Subtypes A (n=13, 46 %), C (n=6, 21 %) and D (n=2, 7 %), as well as a number (25 %) of A/C, C/A, D/A and C/D recombinant forms (n=3, 2, 1 and 1, respectively), were identified. Of the 31 HIV-1 seropositive pregnant women analysed, eight (26 %) transmitted HIV-1 to their infants. Among the eight transmitter mothers, four (4 of 13, 31 %) were infected with HIV-1 subtype A, one (1 of 6, 17 %) with HIV-1 subtype C, none (0 of 2, 0 %) with HIV-1 subtype D and three (3 of 7, 43 %) with HIV-1 subtype recombinant A/C. These findings show no significant differences in the mother-to-child transmissibility of HIV-1 subtypes A, C and D and detected recombinants forms.

scholarly journals Molecular Evidence for Mother-to-Child Transmission of Multiple Variants by Analysis of RNA and DNA Sequences of Human Immunodeficiency Virus Type 1

1998 ◽  
Vol 72 (11) ◽  
pp. 8493-8501 ◽  
Author(s):  
C. Pasquier ◽  
C. Cayrou ◽  
A. Blancher ◽  
C. Tourne-Petheil ◽  
A. Berrebi ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Phylogenetic Analysis ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
Fourth Case ◽  
Immunodeficiency Virus ◽  
Mother To Child

ABSTRACT We have examined the viral selection that may occur during transmission by studying the env gene sequences from four cases of mother-to-child transmission of human immunodeficiency virus type 1. The V3 region sequences were directly amplified from both plasma viral RNA and peripheral blood mononuclear cells containing proviral DNA from mothers at delivery and at the time of diagnosis for children. Transmission occurred perinatally in three cases. The similarity of the viral sequences in each infant sample contrasted with the heterogeneous viral populations in the mothers. Phylogenetic analysis indicated the transmission of one or a few closely related maternal minor virus variants. In contrast, the child virus population in the fourth case was as heterogeneous as that of his mother, and phylogenetic analysis strongly suggested the transmission of multiple maternal variants. This case of multiple transmission was confirmed by analyzing sequences obtained at three times after delivery. Strains with sequences corresponding to the syncytium-inducing phenotype were also transmitted in this fourth case, and this was associated with the rapid development of disease in the child. There was no evidence for transmission of particular viral variants from mother to infant. We have thus described a particular case of vertical human immunodeficiency virus type 1 transmission with the transmission of multiple maternal variants to the infant and a rapid, fatal outcome in the child.

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