scholarly journals Residual Brain Infection in Relapsing‐Fever Borreliosis

2006 ◽  
Vol 193 (10) ◽  
pp. 1451-1458 ◽  
Author(s):  
Diego Cadavid ◽  
Marie Sondey ◽  
Edwin Garcia ◽  
Catherine L. Lawson
Keyword(s):  
Relapsing Fever ◽  
Brain Infection

Persistent brain infection and disease reactivation in relapsing fever borreliosis

2006 ◽  
Vol 8 (8) ◽  
pp. 2213-2219 ◽  
Author(s):  
Christer Larsson ◽  
Marie Andersson ◽  
Jenni Pelkonen ◽  
Betty P. Guo ◽  
Annika Nordstrand ◽  
...  
Keyword(s):  
Relapsing Fever ◽  
Brain Infection ◽  
Disease Reactivation

scholarly journals Concomitant Infection Decreases the Malaria Burden but Escalates Relapsing Fever Borreliosis

2010 ◽  
Vol 78 (5) ◽  
pp. 1924-1930 ◽  
Author(s):  
Jenny Lundqvist ◽  
Christer Larsson ◽  
Maria Nelson ◽  
Marie Andersson ◽  
Sven Bergström ◽  
...  
Keyword(s):  
Mixed Infection ◽  
Fold Increase ◽  
Single Infection ◽  
Relapsing Fever ◽  
Biologically Relevant ◽  
Time To Death ◽  
Malaria Burden ◽  
Brain Infection ◽  
Number Of Patients

ABSTRACT About 500 million cases of malaria occur annually. However, a substantial number of patients who actually have relapsing fever (RF) Borrelia infection can be misdiagnosed with malaria due to similar manifestations and geographic distributions of the two diseases. More alarmingly, a high prevalence of concomitant infections with malaria and RF Borrelia has been reported. Therefore, we used a mouse model to study the effects of such mixed infection. We observed a 21-fold increase in spirochete titers, whereas the numbers of parasitized erythrocytes were reduced 15-fold. This may be explained by polarization of the host immune response toward the intracellular malaria parasite, resulting in unaffected extracellular spirochetes and hosts that succumb to sepsis. Mixed infection also resulted in severe malaria anemia with low hemoglobin levels, even though the parasite counts were low. Overall, coinfected animals had a higher fatality rate and shorter time to death than those with either malaria or RF single infection. Furthermore, secondary malaria infection reactivated a quiescent RF brain infection, which is the first evidence of a clinically and biologically relevant cue for reactivation of RF Borrelia infection. Our study highlights the importance of investigating concomitant infections in vivo to elucidate the immune responses that are involved in the clinical outcome.

Residual brain infection in murine relapsing fever borreliosis can be successfully treated with ceftriaxone

2008 ◽  
Vol 44 (3) ◽  
pp. 262-264 ◽  
Author(s):  
Christer Larsson ◽  
Jenny Lundqvist ◽  
Sven Bergström
Keyword(s):  
Relapsing Fever ◽  
Brain Infection

Relapsing fever

AccessScience ◽  
2015 ◽  
Keyword(s):  
Relapsing Fever

Imported cases of relapsing fever in Germany

2000 ◽  
Vol 4 (51) ◽  
Author(s):  
B Twisselmann
Keyword(s):  
Relapsing Fever ◽  
Imported Cases

Notes on the Epidemic of Relapsing Fever in Liverpool

BMJ ◽  
1870 ◽  
Vol 2 (505) ◽  
pp. 246-246
Author(s):  
R. Gee
Keyword(s):  
Relapsing Fever

scholarly journals Closing the Brief Case: Tick-Borne Relapsing Fever in a Returned Traveler

2020 ◽  
Vol 58 (6) ◽  
Author(s):  
Emily Snavely ◽  
Weston Hymas ◽  
Marc Roger Couturier
Keyword(s):  
Relapsing Fever
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