Immunization with High-Dose Intradermal Recombinant Hepatitis B Vaccine in Healthcare Workers Who Failed to Respond to Intramuscular Vaccination

1995 ◽  
Vol 16 (2) ◽  
pp. 88-91 ◽  
Author(s):  
Robert E. Levitz ◽  
Brian W. Cooper ◽  
Helen C. Regan
2018 ◽  
Vol 33 (3) ◽  
pp. 117-122
Author(s):  
Sumio IWASAKI ◽  
Reiko OYAMADA ◽  
Tsubasa WATANABE ◽  
Kiyomi HASUIKE ◽  
Sumito NAKAMURA ◽  
...  

2002 ◽  
Vol 23 (2) ◽  
pp. 87-90 ◽  
Author(s):  
E. Geoffrey Playford ◽  
Patrick G. Hogan ◽  
Amolak S. Bansal ◽  
Kareena Harrison ◽  
David Drummond ◽  
...  

Objective:To study the humoral immune responses, safety, and tolerability of intradermal recombinant hepatitis B vaccination in healthcare workers (HCWs) nonresponsive to previous repeated intramuscular vaccination.Design:An open, prospective, before–after trial.Setting:A tertiary referral hospital and surrounding district health service in Queensland, Australia.Participants:Hospital and community HCWs nonresponsive to previous intramuscular hepatitis B vaccination.Methods:Intradermal recombinant hepatitis B vaccine was administered every second week for a maximum of 4 doses. Hepatitis B surface antibody (anti-HBs) responses were assessed 2 weeks after each dose.Results:Protective anti-HBs levels developed in 17 (94%) of 18 study subjects. Three doses resulted in seroconversion of all responding subjects and the highest geometric mean antibody concentration. The vaccine was well tolerated.Conclusion:More than 90% of previously nonresponsive HCWs responded to intradermal recombinant hepatitis B vaccine with protective anti-HBs levels.


Infection ◽  
1989 ◽  
Vol 17 (2) ◽  
pp. 70-76 ◽  
Author(s):  
W. Jilg ◽  
Marion Schmidt ◽  
F. Deinhardt

1988 ◽  
Vol 29 (4) ◽  
pp. 211-214 ◽  
Author(s):  
P. M. Mannucci ◽  
A. Gringeri ◽  
M. Morfini ◽  
R. De Biasi ◽  
M. C. Tirindelli ◽  
...  

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