A high intensity focused ultrasound (HIFU) scanning approach is needed to obtain multiple treatment spots for the ablation of large volume tumors, but it will bring some problems such as longer treatment times, the inhomogeneity of temperature and thermal lesions in tissues. Although some optimal control methods have been proposed, it is difficult to take into account the uniformity, efficiency and entirety of thermal lesions. In this study, based on the Helmholtz equation and Pennes’ bio-heat transfer equation, a coupled acoustic-thermal field model is proposed to investigate the relationship between temperature elevation, thermal lesions and neighboring treatment spots, and to analyze the effects of the heating time and acoustic intensity on thermal lesions by the finite element method (FEM). Consequently, optimal control schemes for the heating time and acoustic intensity based on the contribution from neighboring treatment spots to thermal lesions are put forward to reduce treatment times and improve the uniformity of temperature and thermal lesions. The simulation results show that the peak historical temperature elevation on one treatment spot is related to the number, distance and time interval of its neighboring treated spots, and the thermal diffusion from the neighboring untreated spots can slow down the drop of temperature elevation after irradiation, thus both of them affect the final shape of the thermal lesions. In addition, increasing the heating time or acoustic intensity of each treatment spot can expand the overall area of thermal lesions, but it would aggravate the elevation and nonuniformity of the temperature of the treatment region. Through optimizing the heating time, the total treatment time can be reduced from 249 s by 17.4%, and the mean and variance of the peak historical temperature elevation can decrease from 44.64 °C by 13.3% and decrease from 24.6317 by 45%, respectively. While optimizing the acoustic intensity, the total treatment time remains unchanged, and the mean of the peak historical temperature elevation is reduced by 4.3 °C. Under the condition of the same thermal lesions, the optimized schemes can reduce the treatment time, lower the peak of the temperature on treatment spots, and homogenize the temperature distributions. This work is of practical significance for the optimization of a HIFU scanning therapy regimen and the evaluation of its treatment effect.
EP-1874: Treatment time reduction in robotic stereotactic body radiation therapy (SBRT)