Hematological and Cardiometabolic Safety of Clozapine in the Treatment of Very Early Onset Schizophrenia: A Retrospective Chart Review

ABSTRACT:Background:Pulmonary edema (PE) can occur in the early or late period following subarachnoid hemorrhage (SAH). The incidence of each type of PE is unknown and the association with ventricular dysfunction, both systolic and diastolic, has not been described.Methods:Retrospective chart review of 178 consecutive patients with SAH surgically treated over a three-year period. Patients with pulmonary edema diagnosed by a radiologist were included. Early onset SAH was defined as occurring within 12 hours. Cardiac function at the time of the PE was analyzed using hemodynamic and echocardiographic criteria of systolic and diastolic dysfunction. Pulmonary edema was observed in 42 patients (28.8%) and was more often delayed (89.4%). Evidence of cardiac involvement during PE varied between 40 to 100%.Results and conclusions:Pulmonary edema occurs in 28.8% of patients after SAH, and is most commonly delayed. Cardiac dysfunction, both systolic and diastolic, is commonly observed during SAH and could contribute to the genesis of PE after SAH.

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Neuropsychological Deficits in the Prodromal Phase and Course of an Early-Onset Schizophrenia

Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie ◽

10.1024/1422-4917/a000286 ◽

2014 ◽

Vol 42 (3) ◽

pp. 167-176 ◽

Cited By ~ 3

Author(s):

Vanessa Puetz ◽

Thomas Günther ◽

Berrak Kahraman-Lanzerath ◽

Beate Herpertz-Dahlmann ◽

Kerstin Konrad

Keyword(s):

Verbal Memory ◽

Early Onset ◽

Neuropsychological Functioning ◽

Neuropsychological Testing ◽

Clinical Situation ◽

Adolescent Male ◽

Antipsychotic Treatment ◽

Early Onset Schizophrenia ◽

Prodromal Phase ◽

Illness Onset

Objectives: Although clear advances have been achieved in the study of early-onset schizophrenia (EOS), little is known to date about premorbid and prodromal neuropsychological functioning in EOS. Method: Here, we report on a case of an adolescent male with EOS who underwent neuropsychological testing before and after illness onset. Results: Marked cognitive deficits in the domains of attention, set-shifting, and verbal memory were present both pre-onset and during the course of schizophrenia, though only deficits in verbal memory persisted after illness-onset and antipsychotic treatment. Conclusion: The findings of this case study suggest that impairments in the verbal memory domain are particularly prominent symptoms of cognitive impairment in prodromal EOS and persist in the course of the disorder, which further demonstrates the difficult clinical situation of adequate schooling opportunities for adolescent patients with EOS.

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Treatment of Early Onset Schizophrenia Spectrum Disorders (TEOSS)

PsycEXTRA Dataset ◽

10.1037/e648002010-001 ◽

2007 ◽

Author(s):

Linmarie Sikich

Keyword(s):

Early Onset ◽

Schizophrenia Spectrum Disorders ◽

Early Onset Schizophrenia ◽

Schizophrenia Spectrum ◽

Spectrum Disorders

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Auditorisches Training auch bei früher Schizophrenie-Erkrankung wirksam

Fortschritte der Neurologie · Psychiatrie ◽

10.1055/a-1163-9429 ◽

2020 ◽

Vol 88 (08) ◽

pp. 488-489

Keyword(s):

Early Onset ◽

Adult Onset ◽

Early Onset Schizophrenia

Die wenigen Studien zum kognitiven Training bei Patienten mit früh beginnender Schizophrenie (Early-Onset-Schizophrenia, EOS) zeigten einen geringeren Behandlungserfolg als das kognitive Training bei Patienten, die als Erwachsene erkrankt sind (Adult-Onset-Schizophrenia, AOS). Eine Sekundäranalyse zweier Studien prüfte jetzt, ob ein auditorisches Training (AT) bei beiden Patientengruppen unterschiedlich wirksam ist.

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