Serum-Based Phospho-Neurofilament-Heavy Protein as Theranostic Biomarker in Three Models of Traumatic Brain Injury: An Operation Brain Trauma Therapy Study

2019 ◽  
Vol 36 (2) ◽  
pp. 348-359 ◽  
Author(s):  
Zhihui Yang ◽  
Tian Zhu ◽  
Stefania Mondello ◽  
Miis Akel ◽  
Aaron T. Wong ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Trauma ◽  
Trauma Therapy

Levetiracetam Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy

2016 ◽  
Vol 33 (6) ◽  
pp. 581-594 ◽  
Author(s):  
Megan Browning ◽  
Deborah A. Shear ◽  
Helen M. Bramlett ◽  
C. Edward Dixon ◽  
Stefania Mondello ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Trauma ◽  
Trauma Therapy

scholarly journals Simvastatin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy

2016 ◽  
Vol 33 (6) ◽  
pp. 567-580 ◽  
Author(s):  
Andrea Mountney ◽  
Helen M. Bramlett ◽  
C. Edward Dixon ◽  
Stefania Mondello ◽  
W. Dalton Dietrich ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Trauma ◽  
Trauma Therapy ◽  
Simvastatin Treatment

scholarly journals Multi-Center Pre-clinical Consortia to Enhance Translation of Therapies and Biomarkers for Traumatic Brain Injury: Operation Brain Trauma Therapy and Beyond

2018 ◽  
Vol 9 ◽  
Author(s):  
Patrick M. Kochanek ◽  
C. Edward Dixon ◽  
Stefania Mondello ◽  
Kevin K. K. Wang ◽  
Audrey Lafrenaye ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Trauma ◽  
Trauma Therapy

Kollidon VA64 Treatment in Traumatic Brain Injury, Operation Brain Trauma Therapy

2021 ◽  
Author(s):  
Nicole Osier ◽  
Helen M. Bramlett ◽  
Deborah A. Shear ◽  
Stefania Mondello ◽  
Shaun W. Carlson ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Trauma ◽  
Trauma Therapy

scholarly journals Glibenclamide Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy

2020 ◽  
Author(s):  
Ruchira M. Jha ◽  
Stefania Mondello ◽  
Helen M. Bramlett ◽  
C. Edward Dixon ◽  
Deborah A. Shear ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Trauma ◽  
Trauma Therapy

Cyclosporine Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy

2016 ◽  
Vol 33 (6) ◽  
pp. 553-566 ◽  
Author(s):  
C. Edward Dixon ◽  
Helen M. Bramlett ◽  
W. Dalton Dietrich ◽  
Deborah A. Shear ◽  
Hong Q. Yan ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Trauma ◽  
Trauma Therapy

Insight into Pre-Clinical Models of Traumatic Brain Injury Using Circulating Brain Damage Biomarkers: Operation Brain Trauma Therapy

2016 ◽  
Vol 33 (6) ◽  
pp. 595-605 ◽  
Author(s):  
Stefania Mondello ◽  
Deborah A. Shear ◽  
Helen M. Bramlett ◽  
C. Edward Dixon ◽  
Kara E. Schmid ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Damage ◽  
Brain Trauma ◽  
Trauma Therapy ◽  
Clinical Models ◽  
Insight Into

scholarly journals Operation Brain Trauma Therapy: An Exploratory Study of Levetiracetam Treatment Following Mild Traumatic Brain Injury in the Micro Pig

2021 ◽  
Vol 11 ◽  
Author(s):  
Audrey Lafrenaye ◽  
Stefania Mondello ◽  
John Povlishock ◽  
Karen Gorse ◽  
Susan Walker ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Diffuse Axonal Injury ◽  
Brain Trauma ◽  
Morphological Properties ◽  
Trauma Therapy ◽  
Serum Samples ◽  
Post Injury ◽  
Antiepileptic Agent ◽  
Axonal Swellings

Operation brain trauma therapy (OBTT) is a drug- and biomarker-screening consortium intended to improve the quality of preclinical studies and provide a rigorous framework to increase the translational potential of experimental traumatic brain injury (TBI) treatments. Levetiracetam (LEV) is an antiepileptic agent that was the fifth drug tested by OBTT in three independent rodent models of moderate to severe TBI. To date, LEV has been the most promising drug tested by OBTT and was therefore advanced to testing in the pig. Adult male micro pigs were subjected to a mild central fluid percussion brain injury followed by a post-injury intravenous infusion of either 170 mg/kg LEV or vehicle. Systemic physiology was assessed throughout the post-injury period. Serial serum samples were obtained pre-injury as well as at 1 min, 30 min, 1 h, 3 h, and 6 h post-injury for a detailed analysis of the astroglial biomarker glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase L1. Tissue was collected 6 h following injury for histological assessment of diffuse axonal injury using antibodies against the amyloid precursor protein (APP). The animals showed significant increases in circulating GFAP levels from baseline to 6 h post-injury; however, LEV treatment was associated with greater GFAP increases compared to the vehicle. There were no differences in the numbers of APP+ axonal swellings within the pig thalamus with LEV treatment; however, significant alterations in the morphological properties of the APP+ axonal swellings, including reduced swelling area and increased swelling roundness, were observed. Additionally, expression of the neurite outgrowth marker, growth-associated protein 43, was reduced in axonal swellings following LEV treatment, suggesting potential effects on axonal outgrowth that warrant further investigation.

Nicotinamide Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy

2016 ◽  
Vol 33 (6) ◽  
pp. 523-537 ◽  
Author(s):  
Deborah A. Shear ◽  
C. Edward Dixon ◽  
Helen M. Bramlett ◽  
Stefania Mondello ◽  
W. Dalton Dietrich ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Trauma ◽  
Trauma Therapy ◽  
Nicotinamide Treatment

scholarly journals Erythropoietin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy

2016 ◽  
Vol 33 (6) ◽  
pp. 538-552 ◽  
Author(s):  
Helen M. Bramlett ◽  
W. Dalton Dietrich ◽  
C. Edward Dixon ◽  
Deborah A. Shear ◽  
Kara E. Schmid ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Trauma ◽  
Trauma Therapy ◽  
Erythropoietin Treatment
Sign in / Sign up

Export Citation Format

Share Document