scholarly journals P732 Endoscopic Balloon Dilation Of Symptomatic Intestinal Crohn’s disease Strictures: Long-Term Data On Efficacy And Safety In A Cohort Of Patients Followed-up For 10 Years

2019 ◽  
Vol 13 (Supplement_1) ◽  
pp. S487-S488
Author(s):  
D Scimeca ◽  
F Mocciaro ◽  
R Di Mitri ◽  
M Giunta ◽  
S Renna ◽  
...  
2009 ◽  
Vol 136 (5) ◽  
pp. A-656-A-657
Author(s):  
Daniela Scimeca ◽  
Filippo Mocciaro ◽  
Ambrogio Orlando ◽  
Luigi M. Montalbano ◽  
Gennaro D'Amico ◽  
...  

2019 ◽  
Vol 14 (4) ◽  
pp. 557-566 ◽  
Author(s):  
Iago Rodríguez-Lago ◽  
Javier P Gisbert

Abstract Crohn’s disease is a progressive and disabling inflammatory disease involving the gastrointestinal tract. It usually produces inflammatory lesions in the ileocolonic region, but up to half of patients will also develop complications such as strictures in the long term. Indeed, a proportion of patients have progression of the disease with the development of stricturing lesions because there are no drugs that effectively prevent or reverse established fibrosis, and hence these patients are usually treated with surgery or endoscopic balloon dilation. Fibrotic lesions are always associated with some degree of inflammatory changes, but there is little evidence supporting the use of medical therapy in this context. Here, we discuss the most important findings on the possible use of immunomodulators or biologics in the prevention and treatment of intestinal strictures in Crohn’s disease patients. Recent evidence demonstrates that these drugs may also be effective in treating lesions with high levels of collagen deposition, and thus might, at least in some patients, reduce the progression of the disease and bowel damage, and further avoid the need for surgery and a disabling course in the long term.


2004 ◽  
Vol 16 (s1) ◽  
pp. S27-S30 ◽  
Author(s):  
Toshiyuki Matsui ◽  
Sumio Tsuda ◽  
Hiroaki Matake ◽  
Keisuke Ikeda ◽  
Tsuneyoshi Yao

2014 ◽  
Vol 26 (4) ◽  
pp. 545-551 ◽  
Author(s):  
Fumihito Hirai ◽  
Takahiro Beppu ◽  
Noritaka Takatsu ◽  
Yutaka Yano ◽  
Kazeo Ninomiya ◽  
...  

Endoscopy ◽  
1997 ◽  
Vol 29 (07) ◽  
pp. 640-645 ◽  
Author(s):  
T. Matsui ◽  
S. Hatakeyama ◽  
K. Ikeda ◽  
T. Yao ◽  
K. Takenaka ◽  
...  

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